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34784-05-9

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34784-05-9 Usage

General Description

6-Bromoisoquinoline is a chemical compound that belongs to the class of heterocyclic compounds. It is a derivative of isoquinoline, which consists of a six-membered aromatic ring fused to a five-membered nitrogen-containing ring. 6-Bromoisoquinoline is commonly used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. Its bromine-substituted structure makes it a valuable intermediate for the preparation of various biologically active compounds. This chemical has garnered interest in medicinal chemistry due to its potential pharmacological properties, and it has been investigated for its anti-cancer, anti-inflammatory, and anti-microbial activities. Additionally, research has shown that 6-Bromoisoquinoline can serve as a versatile starting material for the synthesis of diverse molecular scaffolds, making it a useful tool in drug development and discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 34784-05-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,7,8 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 34784-05:
(7*3)+(6*4)+(5*7)+(4*8)+(3*4)+(2*0)+(1*5)=129
129 % 10 = 9
So 34784-05-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H6BrN/c10-9-2-1-7-3-4-11-6-8(7)5-9/h1-6H

34784-05-9 Well-known Company Product Price

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  • Aldrich

  • (730521)  6-Bromoisoquinolinemonohydrate  97%

  • 34784-05-9

  • 730521-1G

  • 1,255.41CNY

  • Detail

34784-05-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-bromoisoquinoline

1.2 Other means of identification

Product number -
Other names isoquinoline,6-bromo

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:34784-05-9 SDS

34784-05-9Relevant articles and documents

Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions

Pearson, Stuart E.,Fillery, Shaun M.,Goldberg, Kristin,Demeritt, Julie E.,Eden, Jonathan,Finlayson, Jonathan,Patel, Anil

, p. 4963 - 4981 (2018/12/13)

Isoquinolines activated with sulfamoyl chlorides were reacted with indoles in a 3-component reaction to generate a library of dihydroisoquinoline derivatives. Using a differential protecting group strategy, products could be further derivatised. Synthesis of isoquinoline starting materials using several different methods is also described.

Inhibitors of the detoxifying enzyme of the phytoalexin brassinin based on quinoline and isoquinoline scaffolds

Pedras, M. Soledade C.,Abdoli, Abbas,Sarma-Mamillapalle, Vijay K.

, (2017/08/29)

The detoxification of the phytoalexin brassinin to indole-3-carboxaldehyde and S-methyl dithiocarbamate is catalyzed by brassinin oxidase (BOLm), an inducible fungal enzyme produced by the plant pathogen Leptosphaeria maculans. Twenty-six substituted quinolines and isoquinolines are synthesized and evaluated for antifungal activity against L. maculans and inhibition of BOLm. Eleven compounds that inhibit BOLm activity are reported, of which 3-ethyl-6-phenylquinoline displays the highest inhibitory effect. In general, substituted 3-phenylquinolines show significantly higher inhibitory activities than the corresponding 2-phenylquinolines. Overall, these results indicate that the quinoline scaffold is a good lead to design paldoxins (phytoalexin detoxification inhibitors) that inhibit the detoxification of brassinin by L. maculans.

Luminescent Pt(ii) complexes bearing dual isoquinolinyl pyrazolates: Fundamentals and applications

Ku, Hsiao-Yun,Tong, Bihai,Chi, Yun,Kao, Hao-Che,Yeh, Chia-Chi,Chang, Chih-Hao,Lee, Gene-Hsiang

supporting information, p. 8552 - 8563 (2015/05/20)

A series of four Pt(ii) metal complexes with trans-arranged isoquinolinyl azolates have been prepared, [Pt(Lx)2], x = 1-4, (1-4). The associated chelates possess various substituents; namely: one t-butyl (But) at the 6-position (L1), two But groups at the 5,7-positions (L2), one dip (2,6-di-isopropylphenyl) group at the 6-position (L3), and a single dip group at the 4-position of the 1-isoquinolinyl fragment (L4), respectively. Crystal structures of 1 and 4 were determined to shed light on the relationship of photophysics and packing arrangements. Their photophysical properties were measured and compared, for which the solid-state emission spectra of 2 and 4 are nearly identical to the solution spectra of all the Pt(ii) complexes, showing the formation of isolated molecular entities. In contrast, the Pt(ii) complexes 1 and 3 are found to be sensitive to their morphological states and external stimulus. This is confirmed by the gradual red-shifting of the emission with increasing concentration in the PMMA matrix, and the eventual formation of the broadened, metal-metal-to-ligand charge transfer (MMLCT) emission, by (i) wetting with acetone and drying in air, or (ii) grinding with a mortar and pestle, respectively. Organic light-emitting diodes (OLEDs) were also fabricated using multiple layered architecture and lowered doping concentration (e.g. 8 wt%), the latter is for avoiding dopant aggregation in the emitting layer. The associated OLED performances (i.e. ηmax = 11.5%, 8.5%, and 11.2% for 1, 2 and 3) confirmed their suitability and potential as dopants for phosphorescent OLEDs.

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