82850-31-5Relevant academic research and scientific papers
Polymer-supported hantzsch 1,4-dihydropyridine ester: An efficient biomimetic hydrogen source for the reduction of ketimines and electron-withdrawing group conjugated olefins
Che, Jun,Lam, Yulin
experimental part, p. 1752 - 1758 (2010/09/11)
A polymer-supported Hantzsch 1,4-dihydropyridine ester was observed to be a useful selective reducing agent for the reduction of ketimines and electron-withdrawing conjugated olefins. The rate of the reduction of electron-withdrawing conjugated olefins is dependent on the nature of the conjugated substituents and could be enhanced by microwave irradiation. The reduction of (Z)-α-cyano-β-bromomethylcinnamates to cyclopropane derivatives using polymer-supported Hantzsch 1,4-dihydropyridine ester was found to proceed stereoselectively and in good yields.
An unusual peroxide-mediated amination of cycloalkanes with nitroarenes
Deng, Guojun,Chen, Wenwen,Li, Chao-Jun
supporting information; experimental part, p. 353 - 356 (2009/10/25)
A direct amination of simple cycloalkanes with nitroarenes mediated by peroxides has been discovered. Various secondary arylamines were obtained efficiently from cycloalkanes. The reaction tolerates a wide range of functionalities as well as aqueous condi
Chemoselective reductive amination of aldehydes and ketones by dibutylchlorotin hydride-HMPA complex
Suwa, Toshihiro,Sugiyama, Erika,Shibata, Ikuya,Baba, Akio
, p. 789 - 800 (2007/10/03)
Reductive amination of various aldehydes and ketones has been performed effectively by pentacoordinate chloro-substituted tin hydride complex, Bu2SnClH-HMPA. The tin reagent worked particularly well for the case using weakly basic aromatic amines as starting substrates. Stoichiometric amounts of a substrate and a reducing agent were adequate for the reaction. The Sn-Cl bond in the complex plays an important role for both steps of imine formation and subsequent reduction. Highly chemoselective reduction of carbonyls could be achieved regardless of other functionalities such as halogen, carbon- carbon double bond and hydroxyl groups in the starting carbonyls and amines.
Reduction of imines to amines through use of Cp2MoH2 and protonic acid system
Minato, Makoto,Fujiwara, Yutaka,Ito, Takashi
, p. 647 - 648 (2007/10/02)
Imines are conveniently reduced to the corresponding amines by molybdenum dihydride CpMoH2 under mild conditions in good yields.In the presence of a ketone only an imine was reduced and the ketone was recovered quantitatively.
β-Substituted Organoalkaline Tri- and Tetra-anions; Preparation, Stability, and Reactivity
Barluenga, Jose,Fananas, Francisco J.,Villamana, Jorge,Yus, Miguel
, p. 2685 - 2692 (2007/10/02)
New β,γ-, β,β'-disubstituted organometallic trianions of the type C(Y)C(Y')C(8) and C(Y)CC(Y') (18) (Y = or (*) Y' = O, PhN), β-substituted organodimetallic trianions of the type CC(PhN)C (25) with alkali-metal cations (Li, Na, and K), and a lithiated tetra-anion of the type CC(PhN)C(PhN)C (32) are obtained from the corresponding substituted organomercury(II) compounds via low-temperature mercury-alkali metal transmetallation.The starting organomercurials can be obtained by solvomercuriation from suitable unsaturated systems.These polyanion derivatives are stable species only at temperatures in the range -78 to -100 deg C; at higher temperatures rapid decomposition takes place via either a β-elimination process or proton abstraction from the reaction media.The new polyanionic compounds are characterized by transformation into their deuterio derivatives with deuterium oxide at low temperature.The thermal decomposition of these organometallic intermediates is also reported.The reactivity of the lithiated trianion derived from isopropylaniline (25a) with different agents (ethyl bromide, dimethyl disulphide, and trimethylchlorosilane) in a successive or simultaneous way is studied; this process occurs in a regioselective manner.
Trianions derived from Secondary Amines
Berluenga, Jose,Villamana, Jorge,Fananas, Francisco J.,Yus, Miguel
, p. 355 - 356 (2007/10/02)
New β-substituted homo- and hetero-metallic trianions of the type CC (NPh)C with alkali metal cations (Li, Na, and K) are obtained from β-substituted organomercury compounds via low temperature mercury-alkali metal transmetallation; the lithiated trianion
