82894-84-6

Basic information

• Product Name: 1H-Isoindole, 2,3-dihydro-1,1,3,3-tetraMethyl-
• Synonyms: 1H-Isoindole, 2,3-dihydro-1,1,3,3-tetraMethyl-;1,1,3,3-TetraMethylisoindoline
• CAS NO: 82894-84-6
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.27008
• Mol File: 82894-84-6.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Isoindole, 2,3-dihydro-1,1,3,3-tetraMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole, 2,3-dihydro-1,1,3,3-tetraMethyl-(82894-84-6)
• EPA Substance Registry System: 1H-Isoindole, 2,3-dihydro-1,1,3,3-tetraMethyl-(82894-84-6)

Safety Data

• Hazardous Substances Data: 82894-84-6(Hazardous Substances Data)

Usage

Heterocyclic ring

The compound has a ring structure that contains two nitrogen atoms and four carbon atoms.

TetraMethyl substitution

The compound has four methyl groups attached to the carbon atoms in its structure.

1H-Isoindole, 2,3-dihydro

The compound has a hydrogen atom attached to the isoindole ring in a 1H position and two additional hydrogen atoms in a 2,3-dihydro position.

Organic synthesis

The compound is commonly used in organic synthesis and research.

Pharmaceutical and chemical industries

The compound has potential applications in the pharmaceutical and chemical industries.

Building block

The compound is a valuable building block for the synthesis of complex organic molecules and materials.

Steric and electronic properties

The tetramethyl substitution pattern provides the compound with specific steric and electronic properties that make it useful in various chemical reactions and applications.

Upstream product

• 80037-90-7 1,1,3,3-tetramethyl-2,3-dihydro-1H-isoindol-2-yloxoyl radical 
• 108-98-5 thiophenol 
• 85-44-9 phthalic anhydride 
• 2142-01-0 N-benzylphthalimide 
• 221368-73-6 2-bromo-1,1,3,3-tetramethylisoindoline 
• 2809-93-0 α,α,α',α'-tetramethyldipropargylamine 
• 74-86-2 acetylene 
• 82894-83-5 2-benzyl-1,1,3,3-tetramethylisoindoline 

Downstream Products

• 153709-73-0 N-benzoyl-1,1,3,3-tetramethyl-5-nitroisoindoline 
• 80037-95-2 2-methoxy-1,1,3,3-tetramethyl-2,3-dihydro-1H-isoindole 
• 81913-48-6 2-(2-tert-butoxy-1-phenylethoxy)-1,1,3,3-tetramethyl-2,3-dihydro-1H-isoindole 
• 153709-74-1 N-benzoyl-1,1,3,3-tetramethylisoindoline 

Relevant articles and documents

Reactivity of polyolefins toward cumyloxy radical: Yields and regioselectivity of hydrogen atom transfer

Hydrogen atom abstraction from a series of homopolymers by cumyloxy radicals is examined under solvent-free conditions at temperatures that are relevant to radical-mediated polymer modifications. Abstraction efficiency data acquired for the thermolysis of dicumyl peroxide (DCP) within pure polymer samples establish an order of reactivity: poly(butadiene) (PBD) > poly(ethylene oxide) (PEO) > poly(ethylene) (PE) > poly(propylene) (PP) > poly(isobutylene) (PIB). The regioselectivity of hydrogen transfer from PE, PP, and PIB is assessed by model hydrocarbon experiments involving nitroxyl trapping of the alkyl radicals generated from pentane, 2,4-dimethylpentane, and 2,2,4,4-tetramethylpentane, respectively. Taken together, abstraction efficiency and regioselectivity data are discussed in terms of enthalpic and entropic contributions to H atom transfer rates, with particular emphasis on steric hindrance imposed by methyl substituents on secondary positions within PP and PIB. The utility of polymer oxidizability as a predictive measure of the reactivity of a polymer toward cumyloxyl and vinyltriethoxysilane graft modification is evaluated and discussed.

INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS

Provided herein are compositions and related methods useful for prevention or mitigation of ionizing radiation-induced esophagitis. The compositions comprise compounds comprising a nitroxide-containing group attached to a mitochondria-targeting group. The

2′-Alkynylnucleotides: A Sequence- and Spin Label-Flexible Strategy for EPR Spectroscopy in DNA

Electron paramagnetic resonance (EPR) spectroscopy is a powerful method to elucidate molecular structure through the measurement of distances between conformationally well-defined spin labels. Here we report a sequence-flexible approach to the synthesis of double spin-labeled DNA duplexes, where 2′-alkynylnucleosides are incorporated at terminal and internal positions on complementary strands. Post-DNA synthesis copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with a variety of spin labels enable the use of double electron-electron resonance experiments to measure a number of distances on the duplex, affording a high level of detailed structural information.