82924-82-1

Basic information

• Product Name: N-(4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl)-2-nitrobenzaMide
• Synonyms: Ethanone, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-2-(4-nitrophenyl)-
• CAS NO: 82924-82-1
• Molecular Formula: C₁₉H₂₀N₂O₅
• Molecular Weight: 401.45772
• Mol File: 82924-82-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl)-2-nitrobenzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl)-2-nitrobenzaMide(82924-82-1)
• EPA Substance Registry System: N-(4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl)-2-nitrobenzaMide(82924-82-1)

Safety Data

• Hazardous Substances Data: 82924-82-1(Hazardous Substances Data)

Upstream product

• 104-03-0 4-nitrobenzeneacetic acid 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 50434-36-1 4-nitrophenylacetyl chloride 

Downstream Products

• 82925-02-8 4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine 
• 1018524-30-5 2-(4-Amino-phenyl)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone 

Relevant articles and documents

Synthesis and Activity against Multidrug Resistance in Chinese Hamster Ovary Cells of New Acridone-4-carboxamides

A number of tricyclic carboxamides have been synthesized and tested to evaluate their ability to reverse multidrug resistance in the CHRC/5 cell line.Among them the acridone derivatives were the most potent.A key feature is the presence of a dimethoxybenzyl or phenethylamine cationic site, separated from the tricyclic lipophilic part by a carbamoylphenyl chain.Optimization led to compounds 2 orders of magnitude more active than the prototype inhibitors verapamil and amiodarone.On the basis of in vitro and in vivo activities, 9,10-dihydro-5-methoxy-9-oxo-N-phenyl>-4-acridinecarboxamide (84) has been selected for further development.