82935-42-0Relevant articles and documents
3-Aminomethylbiphenyls. A New Class of Dopamine Receptor Ligands
Thurkauf, Andrew,Yuan, Jun,Chen, Xi,Wasley, Jan W. F.,Paneitz, Gregory,Meade, Robin,Woodruff, Kristine Harris,Huston, Kevin,Ross, Philip C.
, p. 69 - 80 (2007/10/03)
A series of 3-aminomethylbiphenyls were prepared in three steps from 3-phenylbenzoic acid and their affinities for the D2, D3 and D4 dopamine receptor subtypes determined. Most of the compounds described contained unique amine subunits of known dopaminergic agents. The compounds containing the amino tails present in the antipsychotic drugs haloperidol, pimozide and miliperidine displayed selectivity for the D2 receptor. Five-fold selectivity for the D4 receptor was observed in the compound 1-(3-biphenyl)-4-(2-pyrimidyl)piperazine. This selectivity for D4 vs. D2 receptors is comparable to that observed with the atypical antipsychotic clozapine.