82947-13-5

Upstream product

• 102-96-5 (2-nitroethenyl)benzene 
• 93-91-4 1-phenylbutan-1,3-dione 
• 100-52-7 benzaldehyde 
• 5153-67-3 nitrostyrene 

Relevant academic research and scientific papers

Molecular Engineering of β-Substituted Oxoporphyrinogens for Hydrogen-Bond Donor Catalysis

A new class of bifunctional hydrogen-bond donor organocatalyst using oxoporphyrinogens having increased intramolecular hydrogen-bond donor distances is reported. Oxoporphyrinogens are highly non-planar rigid macrocycles containing a multiple hydrogen bond-forming binding site. In this work, we describe the first example of non-planar OxPs as hydrogen-bond donor catalysts prepared using a molecular engineering approach of the binding site for dual activation of substrates. The introduction of β-substituents is key to the catalytic activity and the catalysts are able to catalyze 1,4-conjugate additions and sulfa-Michael additions, as well as, Henry and aza-Henry reactions at low catalyst loadings (≤ 1 mol-%) under mild conditions. Preliminary mechanistic studies have been carried out and a possible reaction mechanism has been proposed based on the bi-functional activation of both substrates through hydrogen-bonding interactions.

1,3-Diamine-Derived Bifunctional Organocatalyst Prepared from Camphor

Chiral 1,2-diamines are privileged structural motifs in organocatalysis, whereas efficient 1,3-diamine-derived organocatalysts are very rare. Herein we report a highly efficient camphor-1,3-diamine-derived squaramide organocatalyst. Its catalytic activity

Bifunctional organocatalysis with squaramide-containing Dawson organo-polyoxotungstates

Two squaramide-containing organo-polyoxometalates (POMs) have been prepared, which efficiently catalyze the addition of dicarbonyl derivatives onto nitroolefins. The POM surface enhances the reactivity of the squaramide, and the hybrid acts as a bifunctio

Asymmetric synthesis of tetrahydropyridines via an organocatalytic one-pot multicomponent Michael/aza-Henry/cyclization triple domino reaction

A low loading of a quinine-derived squaramide efficiently catalyzes the triple-domino Michael/aza-Henry/cyclization reaction between 1,3-dicarbonyl compounds, β-nitroolefins, and aldimines to provide tetrahydropyridines bearing three contiguous stereogeni

A polystyrene-supported, highly recyclable squaramide organocatalyst for the enantioselective Michael addition of 1,3-dicarbonyl compounds to β-nitrostyrenes

A chiral squaramide has been supported onto a polystyrene (PS) resin through a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction and used as a very active, easily recoverable and highly reusable organocatalyst for the asymmetric Michael additio

Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a grinding method

An environmentally benign, fast and convenient protocol has been developed for the Michael addition of 1,3-dicarbonyl compounds to β-nitroalkenes in good to excellent yields by a grinding method under catalyst- and solvent-free conditions.

Acidic alumina as a useful heterogeneous catalyst in the Michael reaction of β-dicarbonyl derivatives with conjugated nitroalkenes

Addition of a variety of 1,3-dicarbonyl derivatives to conjugated nitroalkenes was efficiently performed under heterogeneous catalysis by acidic alumina in the presence of a minimum amount of solvent (Et2O, 0.5 mL/mmol). The procedure allows sa

Michael additions of aldehydes and ketones to β-nitrostyrenes in an ionic liquid

Michael additions of different aldehydes and ketones to β-nitrostyrene and 2-(β-nitrovinyl)thiophene in 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim]PF6) were studied. β-Nitrostyrene was a better acceptor than 2-(β-nitrovinyl)thiophen