Welcome to LookChem.com Sign In|Join Free

CAS

  • or

82956-11-4

Post Buying Request

82956-11-4 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

82956-11-4 Usage

Description

Nafamostat mesylate is a protease inhibitor useful in the treatment of acute pancreatitis. It has anticomplement, anticoagulant, antikallikrein and other activities, and thus may have additional utility in the treatment of autoimmune diseases and disseminated intravascular coagulation.

Originator

Torii (Japan)

Uses

Different sources of media describe the Uses of 82956-11-4 differently. You can refer to the following data:
1. A non-peptide proteaseinhibitor.
2. A non-peptide proteaseinhibitor
3. Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma

Brand name

FUTHAN

Biological Activity

Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.

Biochem/physiol Actions

Nafamostat mesylate is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor.

References

1) Han et al. (2019) Identification of nafamostat mesilate as an inhibitor of the fat mass and obesity-associated protein (FTO) demethylase; Chem. Biol. Interact., 297 80

Check Digit Verification of cas no

The CAS Registry Mumber 82956-11-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,9,5 and 6 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 82956-11:
(7*8)+(6*2)+(5*9)+(4*5)+(3*6)+(2*1)+(1*1)=154
154 % 10 = 4
So 82956-11-4 is a valid CAS Registry Number.
InChI:InChI=1/C19H17N5O2.CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);1H3,(H,2,3,4)

82956-11-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (N0959)  Nafamostat Mesylate  >98.0%(HPLC)

  • 82956-11-4

  • 20mg

  • 390.00CNY

  • Detail
  • TCI America

  • (N0959)  Nafamostat Mesylate  >98.0%(HPLC)

  • 82956-11-4

  • 100mg

  • 1,250.00CNY

  • Detail

82956-11-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Nafamostat Mesylate

1.2 Other means of identification

Product number -
Other names 6-[amino(imino)methyl]-2-naphthyl 4-{[amino(imino)methyl]amino}benzoate dimethanesulfonate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:82956-11-4 SDS

82956-11-4Downstream Products

82956-11-4Relevant articles and documents

Process for Preparing Nafamostat Mesilate and Intermediate Thereof

-

, (2021/10/27)

The present invention provides a method for efficiently producing astaxmostat mesylate through a simple process and a method for producing 6 - amidino -2 - naphthol mesylate in high yield under mild conditions.

Method for preparing of nafamostat mesilate

-

Paragraph 0054; 0055, (2017/01/12)

The present invention discloses a manufacturing method for nafamostat mesylate used as blood coagulation inhibitor where crystalline II type nafamostat mesylate is obtained with high purity and quality as well as regularity. According to the present invention, the manufacturing method for nafamostat mesylate comprises the following steps of: (a) initiating a chemical reaction between 4-guanidino benzoic acidic hydrochloride and 6-amidino-2-naphthol methanesulfonate with the existence of N,N′-Diisopropylcarbodiimide to manufacture the compound shown in Formula 1; (b) adding the manufactured compound in Formula 1 to solvent mixed with water H_2O and saturated sodium hydrogen carbonate NaHCO_3 to manufacture the compound shown in Formula 2; and (c) adding the compound in Formula 2 to solvent, and then adding methanesulfonate to manufacture the nafamostat mesylate compound shown in Formula 3.

AMIDINE COMPOUND

-

, (2008/06/13)

Amidino compounds represented by the formula STR1 and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsine, antiplasmin, antikallikrein and antithrombin agents. Having strong anti-C1 (C1r, C1s) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula STR2 with 6-amidino-2-naphthol and, if necessary, can be transformed into pharmaceuticlly acceptable acid addition salts thereof.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 82956-11-4