82957-06-0

Basic information

• Product Name: 6-AMIDINO-2-NAPHTHOL METHANESULFONATE
• Synonyms: 6-AMIDINO-2-NAPHTHOL METHANESULFONATE;6-AMIDINO-2-NAPHTHOL METHANESULFONIC ACID;6-Amidino-2-naphtol methanesulfonate;Amidinonaphtolmethanesulfonate;6-Amidino-2-naphthol methanesulfonic acid (Nafamostat);6-Amindino-2-naphtholmethanesulfonic acid;6-hydroxynaphthalene-2-carboxamidine mesylate;6-hydroxy-2-naphthiMidaMide Methanesulfonate
• CAS NO: 82957-06-0
• Molecular Formula: CH₄O₃S*C₁₁H₁₀N₂O
• Molecular Weight: 282.32
• EINECS: 1806241-263-5
• Product Categories: APIs Intermediate
• Mol File: 82957-06-0.mol

Chemical Properties

• Boiling Point: 142-149°C(lit.)
• Flash Point: 75°F
• Appearance: /
• Density: 0.876g/mLat 25°C(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Acetonitrile (Slightly), DMSO (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 6-AMIDINO-2-NAPHTHOL METHANESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMIDINO-2-NAPHTHOL METHANESULFONATE(82957-06-0)
• EPA Substance Registry System: 6-AMIDINO-2-NAPHTHOL METHANESULFONATE(82957-06-0)

Safety Data

• Hazardous Substances Data: 82957-06-0(Hazardous Substances Data)

Usage

Uses

Used in Peptide Analysis:
6-Amidino-2-naphthol methanesulfonate is used as an N-terminal derivatization reagent for enhancing peptide fragmentation. This application is particularly beneficial in improving the efficiency and accuracy of mass spectrometry-based peptide identification and characterization processes. By derivatizing the N-terminus of peptides, this reagent aids in the generation of more informative fragmentation patterns, which in turn facilitates better structural elucidation and analysis of peptides.

InChI:InChI=1/C11H10N2O.CH4O3S/c12-11(13)9-2-1-8-6-10(14)4-3-7(8)5-9;1-5(2,3)4/h1-6,14H,(H3,12,13);1H3,(H,2,3,4)

Upstream product

• 75-75-2 methanesulfonic acid 
• 58200-88-7 6-Amidino-2-naphthol 
• 52927-22-7 6-cyano-2-naphthol 
• 765871-54-3 6-Hydroxy-naphthalene-2-carboximidic acid methyl ester 
• 75-36-5 acetyl chloride 
• 78119-82-1 6-hydroxynaphthalene-2-carbaldehyde 
• 15231-91-1 6-bromo-naphthalen-2-ol 

Downstream Products

• 82955-66-6 2-Methyl-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid 
• 82956-37-4 Phenyl-acetic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid 
• 82955-84-8 4-Acetoxy-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid 
• 84729-91-9 4-(Benzyloxycarbonylamino-methyl)-cyclohexanecarboxylic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid 
• 82955-78-0 4-Benzyloxy-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid 
• 82956-15-8 4-Sulfamoyl-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid 
• 82956-23-8 3-Trifluoromethyl-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid 
• 82956-17-0 4-Methylsulfanyl-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid 
• 82956-21-6 4-Acetyl-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid 
• 84729-86-2 6-amidino-2-naphthyl ε-benzyloxycarbonylaminocaproate methanesulfonate 
• 82956-00-1 4-(Benzyloxycarbonylamino-methyl)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid 
• 99558-84-6 4-(2-Diethylamino-ethoxy)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid 
• 99558-82-4 2-[(Z)-Methoxyimino]-3-phenyl-propionic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid 
• 99562-29-5 4-(Methoxyimino-methyl)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid 

Relevant articles and documents

Process for Preparing Nafamostat Mesilate and Intermediate Thereof

The present invention provides a method for efficiently producing astaxmostat mesylate through a simple process and a method for producing 6 - amidino -2 - naphthol mesylate in high yield under mild conditions.

Methanesulfonic acid the naphthalene not takes charge of he intermediate — 6 - amidino - 2 - naphthol armor sulfonate synthetic method

The present invention relates to a new synthesis method for a nafamostat mesylate intermediate 6-amidino-2-naphthol methanesulfonate. According to the new method, 6-hydroxy-2-naphthaldehyde is adopted as a raw material, dimethyl sulfoxide is adopted as a reaction solvent, the dimethyl sulfoxide and hydroxylamine hydrochloride are subjected to an addition elimination reaction to obtain 6-cyano-2-naphthol, the 6-cyano-2-naphthol is subjected to a pinner reaction in a HCl/methanol solution to obtain 6-hydroxy-2-naphthalene imino methyl ester hydrochloride, ammonia gas is introduced to carry out an aminolysis reaction to obtain 6-amidino-2-naphthol, and the 6-amidino-2-naphthol sequentially reacts with sodium bicarbonate and methanesulfonic acid to convert into the 6-amidino-2-naphthol methanesulfonate. According to the present invention, in the new synthesis method, the 6-cyano-2-naphthol preparation in the first step adopts the completely-new method, the use of the highly toxic copper cyanide in the traditional method is avoided, the operations are simple, and the conditions are mild; and the second step adopts the improved pinner method, wherein the reaction of acetyl chloride and methanol is adopted to produce HCl to replace direct introduction of HCl gas into the reaction system, such that the improved method has strong operability and industrialization is easily achieved.