82972-50-7Relevant academic research and scientific papers
Synthesis of γ-keto sulfones by copper-catalyzed oxidative sulfonylation of tertiary cyclopropanols
Konik, Yulia A.,Elek, Gábor Zoltán,Kaabel, Sandra,J?rving, Ivar,Lopp, Margus,Kananovich, Dzmitry G.
, p. 8334 - 8340 (2017/10/23)
Tertiary cyclopropanols undergo ring-opening oxidative sulfonylation to afford γ-keto sulfones when reacting with sulfinate salts in the presence of a copper(ii) acetate catalyst and an oxidant (tert-butyl hydroperoxide or atmospheric oxygen). Various fluoroalkyl, aryl and alkyl sulfinate salts are successfully employed as sulfonylation reagents, affording the corresponding sulfones in up to 94% yields. The experimental protocol is mild and tolerates a number of functionalities in the cyclopropanol substrate. The reaction proceeds via a one-pot oxidation-Michael addition mechanism and can serve as a useful addition to the existing methods for the preparation of γ-keto sulfones based on the sulfa-Michael reaction.
Straightforward radical organic chemistry in neat conditions and "on water"
Shapiro, Nelly,Kramer, Maria,Goldberg, Israel,Vigalok, Arkadi
supporting information; experimental part, p. 582 - 584 (2010/09/05)
Radicals generated during aldehyde oxidation to carboxylic acids can be efficiently trapped under environmentally friendly conditions, either in neat conditions or "on water".
Lewis Acid - Mediated Addition of Lithiated Alkyl Phenyl Sulphones and Oxiranes. A Method for Synthesis of α,β-Unsaturated Ketones
Marczak, S.,Wicha, J.
, p. 1511 - 1520 (2007/10/02)
Efficiency of the reaction of lithiated alkyl aryl sulphones (1-4) with oxiranes (5, 6) is increased by the presence of BF3 or CeCl3.The respective adducts (7-14) were transformed into α,β-unsaturated ketones (15-22) with high yields.
1,4-ADDITION REACTION OF NON-ALLYLIC SULFONYL CARBANION WITH CYCLOPENTENONE DERIVATIVE IN THE PRESENCE OF HMPA. SYNTHESIS OF 15-KETO PROSTAGLANDIN F1
Nokami, Junzo,Ono, Toshio,Kurihara, Hideyuki,Wakabayashi, Shoji
, p. 607 - 608 (2007/10/02)
1,4-Addition reaction of aliphatic (non-allylic) sulfonyl carbanion to cyclopentenone was studied to build the vinyl ketone function at the β position of the carbonyl of cyclopentenone. 15-Keto PG F1 (6) was synthesized from sulfone ketal 1 and
