82983-19-5

Upstream product

• 860375-05-9 (4-chloro-benzyl)-piperidinomethyl-malonic acid 
• 123-31-9 hydroquinone 
• 50-00-0 formaldehyd 
• 21405-64-1 <(4-chlorophenyl)methyl>propanedioic acid 
• 20566-50-1 ethyl 2-(4-chlorobenzyl)-acrylate 
• 139413-75-5 methyl (2Z)-2-(bromomethyl)-3-(4-chlorophenyl)prop-2-enoate 
• 131469-67-5 methyl 2-[1-hydroxy-1-(4-chlorophenyl)methyl]acrylate 
• 104-88-1 4-chlorobenzaldehyde 
• 1367876-25-2 [(Z)-3-(4-chlorophenyl)-2-methoxycarbonyl-2-propenyl]triphenylphosphonium bromide 
• 622-95-7 4-chlorobenzyl bromide 
• 17449-02-4 p-chlorobenzylidenepropane-1,3-dioic acid 
• 123-25-1 succinic acid diethyl ester 

Downstream Products

• 1282061-24-8 C₁₉H₁₈ClNO 
• 115355-27-6 4-chloro-α-<((R,S)-acetylthio)methyl>benzenepropanoic acid 
• 111510-65-7 (R)-2-[2-Benzoylsulfanylmethyl-3-(4-chloro-phenyl)-propionylamino]-3-ethylsulfanyl-propionic acid 
• 107673-25-6 (R)-2-[3-(4-Chloro-phenyl)-2-mercaptomethyl-propionylamino]-3-ethylsulfanyl-propionic acid 
• 111510-55-5 Thiobenzoic acid S-[2-chlorocarbonyl-3-(4-chloro-phenyl)-propyl] ester 
• 115370-17-7 (R)-2-[(S)-2-Acetylsulfanylmethyl-3-(4-chloro-phenyl)-propionylamino]-3-benzylsulfanyl-propionic acid ethyl ester 
• 115370-16-6 (R)-2-[(R)-2-Acetylsulfanylmethyl-3-(4-chloro-phenyl)-propionylamino]-3-benzylsulfanyl-propionic acid ethyl ester 
• 111510-44-2 2-Benzoylsulfanylmethyl-3-(4-chloro-phenyl)-propionic acid 

Relevant academic research and scientific papers

Microwave-assisted synthesis of the (E)-α-methylalkenoate framework from multifunctionalized allylic phosphonium salts

A convenient and general microwave-assisted method for the synthesis of stereochemically defined α-methylalkenoic acids and esters from allylic phosphonium salts in a basic aqueous medium is described. A selective preparation of acids or esters was dependent on the base (NaOH or NaHCO 3) employed in the reaction and could be achieved with good to excellent yields under mild conditions in the absence of hydrides and reducing agents.

Pd(II)-catalyzed intramolecular amidoarylation of alkenes with molecular oxygen as sole oxidant

Stereoselective palladium-catalyzed synthesis of structurally versatile indoline derivatives, using molecular oxygen as the sole oxidant, is described. New C-N and C-C bonds form across an alkene in an intramolecular manner. The C-N bond-forming step proceeds via a syn-amidopalladation pathway. The moderate kinetic isotope effects (intramolecular KIE = 3.56) suggest that electrophilic aromatic substitution occurs in the arylation step.

BETA-MERCAPTO-PROPANAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES

Compounds of formula STR1 wherein R, R 1, R 2, Het and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients are described. The compounds of formula I are useful in the treatment of cardiovascular diseases.

Beta-mercapto-propanamide derivatives useful in the treatment of cardiovascular diseases

Compounds of formula wherein R, R1, R2, Het and nhave the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients are described. The compounds of formula I are useful in the treatment of cardiovascular diseases.

Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure- activity relationship studies of methionine and S-alkylcysteine derivatives

A broad series of N-(3-mercaptoacyl) amino acid derivatives was evaluated for their ability to inhibit atriopeptidase (neutral endopeptidase, EC 3.4.24.11) in vitro and in vivo. Structural parameters studied were (i) the substituent on the 2-position of the 3-mercaptopropionyl moiety, (ii) the amino acid component, (iii) the S-terminal derivative, and (iv) the C- terminal derivative. Optimum activity was observed for derivatives of methionine and S-alkylcysteines. N-[3-Mercapto-2(S)-[(2- methylphenyl)methyl]-1-oxopropyl]-L-methionine was identified as a highly effective inhibitor of atriopeptidase meriting evaluation as a potential cardiovascular therapeutic agent.