115355-27-6

Upstream product

• 82983-19-5 2-(4-chlorobenzyl)-propenoic acid 
• 507-09-5 tiolacetic acid 
• 21405-64-1 <(4-chlorophenyl)methyl>propanedioic acid 
• 17449-02-4 p-chlorobenzylidenepropane-1,3-dioic acid 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 115370-16-6 (R)-2-[(R)-2-Acetylsulfanylmethyl-3-(4-chloro-phenyl)-propionylamino]-3-benzylsulfanyl-propionic acid ethyl ester 
• 115370-17-7 (R)-2-[(S)-2-Acetylsulfanylmethyl-3-(4-chloro-phenyl)-propionylamino]-3-benzylsulfanyl-propionic acid ethyl ester 
• 161952-14-3 N-(2-ethoxycarbonyl-4-pyrrolyl)-3-acetylthio-2-(4-chlorobenzyl)-propanamide 

Relevant academic research and scientific papers

BETA-MERCAPTO-PROPANAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES

Compounds of formula STR1 wherein R, R 1, R 2, Het and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients are described. The compounds of formula I are useful in the treatment of cardiovascular diseases.

Beta-mercapto-propanamide derivatives useful in the treatment of cardiovascular diseases

Compounds of formula wherein R, R1, R2, Het and nhave the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients are described. The compounds of formula I are useful in the treatment of cardiovascular diseases.

Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure- activity relationship studies of methionine and S-alkylcysteine derivatives

A broad series of N-(3-mercaptoacyl) amino acid derivatives was evaluated for their ability to inhibit atriopeptidase (neutral endopeptidase, EC 3.4.24.11) in vitro and in vivo. Structural parameters studied were (i) the substituent on the 2-position of the 3-mercaptopropionyl moiety, (ii) the amino acid component, (iii) the S-terminal derivative, and (iv) the C- terminal derivative. Optimum activity was observed for derivatives of methionine and S-alkylcysteines. N-[3-Mercapto-2(S)-[(2- methylphenyl)methyl]-1-oxopropyl]-L-methionine was identified as a highly effective inhibitor of atriopeptidase meriting evaluation as a potential cardiovascular therapeutic agent.