83-17-0Relevant articles and documents
Synthesis, molecular structure and antioxidant activity of (E)-4-[Benzylideneamino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, a Schiff base ligand of 4-aminoantipyrine
Alam, Mohammad Sayed,Lee, Dong-Ung
, p. 93 - 102 (2012)
In this study, the title compound, C18H17N 3O (M r = 291.35), was synthesized by the condensation reaction of 4-amino-1,5-dimethyl-2-phenylpyrazole-3-one and benzaldehyde. Single-crystal X-ray diffraction data r
Synthesis, spectroscopic characterization and antibacterial activity of some chlorosulphoxide ruthenium(II) and ruthenium(III) complexes of 4-(benzylideneamino)-1,2-dimethyl-2-phenyl-1,2-dihydropyrazole-3-one, schiff base
Shukla, Satyendra N.,Gaur, Pratiksha,Prasad, Mahender,Agarwal, Kavita,Kaur, Harpreet,Setua, Deepak K.,Mehrotra, Ripul,Prasad, Mamta,Srivastava, Radhey S.
, p. 159 - 165 (2010)
In present work we report the synthesis of five complexes of three different formulations, viz. [cis-RuCl2(SBANTP)2]; [trans-RuCl2SBANTP)2]; and [RuCl4(SBANTP)-] [X]+; where [X]+
Synthesis, Spectroscopy, and Anticancer Activity of Two New Nanoscale Au(III) N4 Schiff Base Complexes
Naglah,Al-Omar,Kalmouch,Gobouri,Abdel-Hafez,El-Megharbel,Refat
, p. 1702 - 1706 (2019)
Mononuclear Au(III) Schiff base complexes are synthesized by the reaction of 4-aminoantipyrine with hydrazine. The chemical structures of new Schiff bases and their Au(III) complexes are elucidated from their conductance, XRD, and spectroscopic (IR, UV-Vi
Preparation of a simple biocompatible magnetite@citric acid: An efficient reusable solid acid catalyst for the rapid synthesis of antipyrine Schiff’s bases and study of their radical scavenging potential
Kumari, Mitlesh,Gupta, Ragini,Jain, Yachana
supporting information, p. 529 - 538 (2019/02/01)
Citric acid immobilized magnetic nanoparticles (MNPs@CA) have been synthesized and used for the preparation of bio-important antipyrine (1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one) derived Schiff’s bases (3a–k) in lesser reaction time with very hi
Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
Tok, Fatih,Ko?yi?it-Kaymak??o?lu, Bedia,Sa?l?k, Begüm Nurpelin,Levent, Serkan,?zkay, Yusuf,Kaplanc?kl?, Zafer As?m
, p. 41 - 50 (2018/11/27)
In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical characterization of the compounds was confirmed using IR, 1H NMR, 13C NMR and mass spectroscopies. The inhibitory potency of synthesized compounds was investigated towards acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and monoamine oxidases A and B (MAO-A and MAO-B) enzymes. Some of the compounds displayed significant inhibitory activity against AChE and MAO-B enzymes, respectively. According to AChE enzyme inhibition assay, compounds 3e and 3g were found as the most potent derivatives with IC50 values of 0.285 μM and 0.057 μM, respectively. Also, compounds 3a (IC50 = 0.114 μM), 3h (IC50 = 0.049 μM), and 3i (IC50 = 0.054 μM) were the most active derivatives against MAO-B enzyme activity. So as to understand inhibition type, enzyme kinetics studies were carried out. Furthermore, molecular docking studies were performed to define and evaluate the interaction mechanism between compounds 3g and 3h and related enzymes. ADME (Absorption, Distribution, Metabolism, and Excretion) and BBB (Blood, Brain, Barier) permeability predictions were applied to estimate pharmacokinetic profiles of synthesized compounds.
Exploring aggregation-induced emission through tuning of ligand structure for picomolar detection of pyrene
Ghosh, Milan,Ta, Sabyasachi,Lohar, Sisir,Das, Sudipta,Brand?o, Paula,Felix, Vitor,Das, Debasis
, (2018/12/11)
Tuning of ligand structures through controlled variation of ring number in fused-ring aromatic moiety appended to antipyrine allows detection of 7.8?×?10?12?M pyrene via aggregation-induced emission (AIE) associated with 101-fold fluorescence e
Characterization of antimicrobial, antioxidant, and leishmanicidal activities of Schiff base derivatives of 4-aminoantipyrine
Teran, Rommy,Guevara, Rommel,Mora, Jessica,Dobronski, Lizeth,Barreiro-Costa, Olalla,Beske, Timo,Pérez-Barrera, Jorge,Araya-Maturana, Ramiro,Rojas-Silva, Patricio,Poveda, Ana,Heredia-Moya, Jorge
, (2019/08/07)
Our main interest is the characterization of compounds to support the development of alternatives to currently marketed drugs that are losing effectiveness due to the development of resistance. Schiff bases are promising biologically interesting compounds
Antipyrine cationic surfactants capping silver nanoparticles as potent antimicrobial agents against pathogenic bacteria and fungi
Aiad,Marzouk, Magda I.,Shaker, Soheir A.,Ebrahim, Nagwa E.,Abd-Elaal, Ali A.,Tawfik, Salah M.
, p. 572 - 583 (2017/09/01)
Development of effective anti-microbial agents has been hindered by the emergence of bacterial strains with multi-drug resistance. In this article, we report an efficient synthesis of silver nanoparticle (AgNP) by capping with a synthetic cationic surfact
Synthesis of Nano-Metric Gold Complexes with New Schiff Bases Derived from 4-Aminoantipyrene, Their Structures and Anticancer Activity
Abou Melha,Al-Hazmi,Refat
, p. 3043 - 3051 (2018/02/21)
Two new Schiff bases derived from combination of 4-aminoantipyrine with ethylenediamine (L1) or benzaldehyde (L2), gave Au(III) complexes. Their structures were elucidated from microanalytical, magnetic, conductance, and FT-IR, UV-Vi
DNA binding propensity and nuclease efficacy of biosensitive Schiff base complexes containing pyrazolone moiety: Synthesis and characterization
Paulpandiyan, Rajakkani,Raman, Natarajan
, p. 374 - 382 (2016/07/19)
A series of novel Co(II), Cu(II), Ni(II) and Zn(II) complexes (1–8) were synthesized from pyrazolone precursor Schiff base(s), obtained by the condensation of 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one (4–aminoantipyrine) with cinnamaldehyde/benzalde
