83-26-1

Basic information

• Product Name: PINDONE
• Synonyms: 1,3-Indandione, 2-pivaloyl-;1,3-Indandione, 2-pivalyl-;1H-Indene-1,3(2H)-dione, 2-(2,2-dimethyl-1-oxopropyl)-;2-(2,2-dimethyl-1-oxopropyl)-1H-indene-1,3-(2H)-dione;2-(2,2-dimethyl-1-oxopropyl)-1h-indene-1,3(2h)-dione;2-(2,2-dimethyl-1-oxopropyl)-1h-indene-3(2h)-dione;2-(2,2-Dimethylpropanoyl)-1H-indene-1,3(2H)-dione;2-(Trimetil-acetil)-indan-1,3-dione
• CAS NO: 83-26-1
• Molecular Formula: C₁₄H₁₄O₃
• Molecular Weight: 230.26
• EINECS: 201-462-8
• Mol File: 83-26-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 108-110°
• Boiling Point: 312.25°C (rough estimate)
• Flash Point: -13.169°C
• Appearance: solid
• Density: 1.1914 (rough estimate)
• Vapor Pressure: 76.833mmHg at 25°C
• Refractive Index: 1.5557 (estimate)
• Storage Temp.: APPROX 20°C
• Solubility: Soluble in most organic solvents (Worthing and Hance, 1991)
• PKA: 3.47±0.10(Predicted)
• Water Solubility: 18 ppm at 25 °C (Gunther et al., 1968)
• Merck: 13,7526
• BRN: 2051258
• CAS DataBase Reference: PINDONE(CAS DataBase Reference)
• NIST Chemistry Reference: PINDONE(83-26-1)
• EPA Substance Registry System: PINDONE(83-26-1)

Safety Data

• Hazard Codes: T,N
• Statements: 25-48/25-50/53
• Safety Statements: 37-45-60-61
• RIDADR: 3027
• WGK Germany: 3
• RTECS: NK6300000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 83-26-1(Hazardous Substances Data)

Usage

Chemical Properties

Pindone is a bright yellow crystalline solid or powder. May turn yellow-brown on contact with air. Nearly odorless.

Uses

Different sources of media describe the Uses of 83-26-1 differently. You can refer to the following data:
1. Insecticide; rodenticide
2. Pindone may be used as an analytical reference standard for the quantification of the analyte in biological samples using different chromatography techniques.

General Description

Yellow solid or powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Ketones, such as PINDONE, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Health Hazard

Pindone is a vitamin K antagonist and causes inhibition of prothrombin formation, which results in hemorrhage. There are no reports of effects in humans.

Fire Hazard

Flash point data for PINDONE are not available, but PINDONE is probably combustible.

Safety Profile

Poison by ingestion, intravenous, and parenteral routes. Causes reduced blood clotting, which leads to hemorrhaging. Used as an anticoagulant and rodenticide. When heated to decomposition it emits acrid smoke and irritating fumes. See also WARFARIN.

Potential Exposure

Pindone is used as an anticoagulant and rodenticide. A potential danger to those involved in manufacture, formulation and application of this chemical

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Incompatibilities

Ketone substances are incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrated amines; azo, diazo, azido compounds, carbamates, organic cyanates.

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

InChI:InChI=1/C5H9O/c1-5(2,3)4-6/h1-3H3

Upstream product

• 82501-31-3 C₂₈H₃₂O₈ 
• 609-67-6 2-Iodobenzoyl chloride 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 131-11-3 phthalic acid dimethyl ester 
• 88-67-5 2-Iodobenzoic acid 
• 1396604-89-9 C₁₃H₁₅IO₂ 
• 1864-94-4 phenyl formate 

Downstream Products

• 85301-72-0 3-tert-Butyl-1-phenyl-1H-indeno[1,2-c]pyrazol-4-one 
• 82501-33-5 3-t-Butylindeno<1,2-c>isoxazol-4-one 
• 85301-77-5 2-methyl-3-t-butylindeno<1,2-c>pyrazol-4(1H)-one 
• 87206-99-3 1-carbamoyl-3-tert-butyl-3a,8b-dihydro-8b-hydroxyindeno<1,2-c>pyrazol-4-one 
• 82501-29-9 3-tert-Butyl-indeno[1,2-c]isoxazol-4-one oxime 
• 82501-31-3 C₂₈H₃₂O₈ 
• 82501-30-2 2-Pivaloyl-3-amino-2-inden-1-one 
• 82501-28-8 8-t-butylindeno<1,2-c>isoxazol-7-one 
• 87206-95-9 3-tert-butyl-3a,8b-dihydro-8b-hydroxyindeno<1,2-c>isoxazol-4-one 
• 577-56-0 2-acetyl-benzoic acid 
• 56767-21-6 3-(1,1-dimethylethyl)indeno<1,2-c>pyrazol-4(1H)-one 

Relevant articles and documents

Palladium-Catalyzed Carbonylative Annulation Reactions Using Aryl Formate as a CO Source: Synthesis of 2-Substituted Indene-1,3(2H)-dione Derivatives

An efficient synthesis of 2-substituted indene-1,3(2H)-diones from stable and readily available 1-(2-halophenyl)-1,3-diones by employing phenyl formate as a CO source has been developed. The reaction occurred via palladium-catalyzed intramolecular carbonylative annulation using K3PO4 as a base and DMSO as a solvent at 95 °C. In this protocol, the reaction showed a broad substrate scope with good to excellent yields.