83-66-9 Hazards Identification
Pictogram(s):
Signal:
Warning
GHS Hazard Statements:
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (28.89%): Causes skin irritation [Warning Skin corrosion/irritation]
Precautionary Statement Codes:
P264, P270, P280, P301+P317, P302+P352, P321, P330, P332+P317, P362+P364, and P501
Hazard Classes and Categories:
Acute Tox. 4 (100%)
Skin Irrit. 2 (28.89%)
Acute toxicity - category 4
Specific target organ toxicity (repeated exposure) - category 1
Reproductive toxicity - category 2
Hazards Summary:
A moderate skin irritant; Causes spinal cord demyelination and changes in testicular weight in 90-day dermal studies of rats; Causes muscle weakness, weight loss, brain and spinal cord demyelination in repeated-dose oral studies of rats; [RTECS] Widely used fragrance implicated in contact photosensitivity. [ChemIDplus] Positive photopatch test results and photoallergic contact dermatitis have been reported; [HSDB] Evidence of photosensitivity, neurotoxicity, and penetration through human skin with slow excretion; No skin sensitization observed in maximization study of 25 volunteers; [EC: SCCNFP] A skin and moderate eye irritant; Toxic by ingestion; [Alfa Aesar MSDS]
83-66-9 Usage
Uses
Used in Cosmetics Industry:
4-tert-Butyl-2,6-dinitro-3-methoxytoluene is used as an artificial human musk in cosmetics for its ability to provide a pleasant and long-lasting scent. It is a popular alternative to natural musk due to its cost-effectiveness, availability, and consistent quality.
Used in Wastewater Treatment:
4-tert-Butyl-2,6-dinitro-3-methoxytoluene is utilized in the treatment of wastewaters for its effectiveness in eliminating or reducing the presence of pollutants and contaminants. Its chemical properties allow it to interact with various impurities, facilitating their removal and resulting in cleaner water.
Air & Water Reactions
Insoluble in water.
Fire Hazard
The flash point of 4-tert-Butyl-2,6-dinitro-3-methoxytoluene has not been determined, but 4-tert-Butyl-2,6-dinitro-3-methoxytoluene is probably combustible.
Safety Profile
A poison by ingestion.
Mutation data reported. A skin irritant.
When heated to decomposition it emits
toxic fumes of NO,. See also AROMATIC
AMINES.
Check Digit Verification of cas no
The CAS Registry Mumber 83-66-9 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 3 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 83-66:
(4*8)+(3*3)+(2*6)+(1*6)=59
59 % 10 = 9
So 83-66-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H16N2O5/c1-7-9(13(15)16)6-8(12(2,3)4)11(19-5)10(7)14(17)18/h6H,1-5H3
83-66-9Relevant academic research and scientific papers
Synthesis method of musk ambrette
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Paragraph 0027; 0031; 0036; 0041, (2017/12/29)
The invention provides a synthesis method of musk ambrette. The synthesis method comprises the following steps of (1) mixing m-cresol, a phase transfer catalyst, a water solution of strong alkali and chloromethane, reacting and then generating m-methoxytoluene; and (2) mixing a catalyst and a solvent, dropwise adding the m-methoxytoluene for 0.5-2h, dropwise adding tert-butyl chloride for 0.5-2h, then reacting for 3-5h and generating tertiary butyl methoxyl methylbenzene. According to the synthesis method of the musk ambrette, methylanisole (replenishing sodium hydroxide to an aqueous alkaline solution, filtering out sodium chloride and then recycling) is synthesized by m-cresol and chloromethane in the water solution of strong alkali, so that compared with a traditional production technology, the yield is improved, treatment of waste water is reduced, manpower resource is saved, energy consumption is reduced and the synthesis method is safer and more reliable.
Non-acid synthesis of nitro musks based on the ozone-mediated nitration using nitrogen dioxide
Suzuki, Hitomi,Hisatome, Kaori,Nonoyama, Nobuaki
, p. 1291 - 1293 (2007/10/03)
Three nitro musks, musk xylol 1, musk ketone 2 and musk ambrette 3, were prepared in good to moderate yield by direct polynitration of the respective aromatic materials with nitrogen dioxide in the presence of ozone.
