88-40-4

Basic information

• Product Name: 2-tert-butyl-5-methylanisole
• Synonyms: 2-tert-butyl-5-methylanisole;1-(1,1-Dimethylethyl)-2-methoxy-4-methylbenzene;1-Methoxy-2-tert-butyl-5-methylbenzene;3-Methoxy-4-tert-butyltoluene;4-tert-Butyl-3-methoxytoluene
• CAS NO: 88-40-4
• Molecular Formula: C₁₂H₁₈O
• Molecular Weight: 178.27072
• EINECS: 201-827-1
• Mol File: 88-40-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 23-24 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 224.3°C at 760 mmHg
• Flash Point: 90°C
• Appearance: /
• Density: 0.907g/cm³
• Vapor Pressure: 0.137mmHg at 25°C
• Refractive Index: 1.483
• CAS DataBase Reference: 2-tert-butyl-5-methylanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-butyl-5-methylanisole(88-40-4)
• EPA Substance Registry System: 2-tert-butyl-5-methylanisole(88-40-4)

Safety Data

• Hazardous Substances Data: 88-40-4(Hazardous Substances Data)

Usage

General Description

2-tert-butyl-5-methylanisole, also known as orivone, is a synthetic chemical compound commonly used in the fragrance and flavor industry. It is a clear, colorless liquid with a sweet, floral odor, and is often used as a key ingredient in perfumes, colognes, and cosmetic products. This chemical is highly valued for its ability to provide a long-lasting, sweet, and fruity scent, and is particularly popular in floral and fruity fragrance compositions. It is also used in flavoring agents and food products to impart a sweet, fruity aroma. 2-tert-butyl-5-methylanisole is considered safe for use in these applications when used in accordance with regulations and guidelines set by regulatory authorities.

InChI:InChI=1/C12H18O/c1-9-6-7-10(12(2,3)4)11(8-9)13-5/h6-8H,1-5H3

Upstream product

• 75-65-0 tert-butyl alcohol 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 507-20-0 tertiary butyl chloride 
• 78-83-1 2-methyl-propan-1-ol 
• 74-87-3 methylene chloride 
• 88-60-8 2-tert-Butyl-5-methylphenol 
• 7446-70-0 aluminium trichloride 
• 86119-84-8 phosphoric acid 
• 513-36-0 isobutyryl chloride 
• 7647-01-0 hydrogenchloride 
• 115-11-7 isobutene 
• 507-19-7 t-butyl bromide 
• 77-78-1 dimethyl sulfate 
• 108-39-4 3-methyl-phenol 

Downstream Products

• 83-66-9 musk ambrette 
• 3606-21-1 5-methoxy-2,4-dinitrotoluene 
• 24456-96-0 2-tert-butyl-5-methyl-1,4-benzoquinone 
• 71850-79-8 2-tert-butyl-5-methyl-4-nitro-anisole 
• 79822-46-1 4-(1,1-dimethylethyl)-3-(methoxy)benzoic acid 
• 26822-00-4 4-bromo-2-tert-butyl-5-methyl-anisole 
• 26821-98-7 2-tert-butyl-4-chloromethyl-5-methyl-anisole 
• 107342-43-8 6-tert-butyl-3-methyl-2-nitro-anisole 
• 873990-70-6 5-tert-butyl-4-methoxy-2-methyl-benzaldehyde 
• 874521-29-6 2,4-di-tert-butyl-5-methyl-anisole 
• 88-60-8 2-tert-Butyl-5-methylphenol 
• 113137-99-8 1-(tert-butyl)-5-iodo-2-methoxy-4-methylbenzene 
• 38512-82-2 3-methoxy-4-nitrotoluene 
• 135546-09-7 2,4-di-tert-butyl-5-methyl-3,6-dinitro-anisole 

Relevant articles and documents

Synthesis method of musk ambrette

The invention provides a synthesis method of musk ambrette. The synthesis method comprises the following steps of (1) mixing m-cresol, a phase transfer catalyst, a water solution of strong alkali and chloromethane, reacting and then generating m-methoxytoluene; and (2) mixing a catalyst and a solvent, dropwise adding the m-methoxytoluene for 0.5-2h, dropwise adding tert-butyl chloride for 0.5-2h, then reacting for 3-5h and generating tertiary butyl methoxyl methylbenzene. According to the synthesis method of the musk ambrette, methylanisole (replenishing sodium hydroxide to an aqueous alkaline solution, filtering out sodium chloride and then recycling) is synthesized by m-cresol and chloromethane in the water solution of strong alkali, so that compared with a traditional production technology, the yield is improved, treatment of waste water is reduced, manpower resource is saved, energy consumption is reduced and the synthesis method is safer and more reliable.

Synthesis of Substituted Dibenzophospholes. Part 8. Synthesis and Resolution of Atropisomers of a 4,6-Diaryldibenzophosphole

Regiospecific replacement of the 4''- and 6'-nitro groups in a 2,2'',4'',6'-teranitro-m-quaterphenyl by alkoxy groups has been effected in two ways: (i) the dialkali salts of α-oximinoalkanoic acids replaced one nitro group by a hydroxy group; after O-alkylation the other alkoxydenitration was effected by sodium benzaldehyde oxime followed by O-alkylation; (ii) both nitro groups were replaced by treatment with sodium 2,2-dimethoxy-1,2-diphenylethanone oximate followed by acidic hydrolysis, alkaline cleavage, and O-alkylation.From the product, synthetic procedures already developed gave 3,7-di-isopropoxy-5-methoxy-4,6-bis-(4-methoxy-2-methyl)dibenzophosphole 5-oxide, separated by chromatography into one racemic and two meso forms.The thermal interconversion of the three forms was demonstrated and measured.The racemic form was resolved by high-performance liquid chromatography (h.p.l.c.) on a chiral column.

A resin-promoted Williamson's alkyl aryl ether synthesis. Methylation of 2-tert-butyl-5-methylphenol with methyl chloride

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