88-40-4

Usage

Uses

Used in Fragrance Industry:
2-tert-butyl-5-methylanisole is used as a fragrance ingredient for its distinctive sweet, fruity aroma, which is particularly favored in floral and fruity fragrance compositions. It enhances the longevity and complexity of scents in perfumes, colognes, and other cosmetic products.
Used in Flavor Industry:
In the flavor industry, 2-tert-butyl-5-methylanisole is used as a flavoring agent to impart a sweet, fruity aroma to food products, contributing to the overall taste and sensory experience of these items.
Used in Cosmetic Products:
2-tert-butyl-5-methylanisole is used as a key component in cosmetic formulations to add a pleasant, long-lasting scent, thereby enhancing the appeal and consumer experience of these products.

InChI:InChI=1/C12H18O/c1-9-6-7-10(12(2,3)4)11(8-9)13-5/h6-8H,1-5H3

Upstream product

• 513-36-0 isobutyryl chloride 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 115-11-7 isobutene 
• 75-65-0 tert-butyl alcohol 
• 507-20-0 tertiary butyl chloride 
• 78-83-1 2-methyl-propan-1-ol 
• 74-87-3 methylene chloride 
• 88-60-8 2-tert-Butyl-5-methylphenol 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 7446-70-0 aluminium trichloride 
• 86119-84-8 phosphoric acid 
• 7647-01-0 hydrogenchloride 
• 507-19-7 t-butyl bromide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 83-66-9 musk ambrette 
• 3606-21-1 5-methoxy-2,4-dinitrotoluene 
• 24456-96-0 2-tert-butyl-5-methyl-1,4-benzoquinone 
• 71850-79-8 2-tert-butyl-5-methyl-4-nitro-anisole 
• 79822-46-1 4-(1,1-dimethylethyl)-3-(methoxy)benzoic acid 
• 26822-00-4 4-bromo-2-tert-butyl-5-methyl-anisole 
• 26821-98-7 2-tert-butyl-4-chloromethyl-5-methyl-anisole 
• 107342-43-8 6-tert-butyl-3-methyl-2-nitro-anisole 
• 873990-70-6 5-tert-butyl-4-methoxy-2-methyl-benzaldehyde 
• 101863-98-3 1-tert-butyl-2-methoxy-4-methyl-5-(toluene-4-sulfonyl)-benzene 
• 874521-29-6 2,4-di-tert-butyl-5-methyl-anisole 
• 88-60-8 2-tert-Butyl-5-methylphenol 
• 113137-99-8 1-(tert-butyl)-5-iodo-2-methoxy-4-methylbenzene 
• 19404-15-0 3-methyl-2,4,6-trinitro-anisole 

Relevant academic research and scientific papers

Synthesis method of musk ambrette

The invention provides a synthesis method of musk ambrette. The synthesis method comprises the following steps of (1) mixing m-cresol, a phase transfer catalyst, a water solution of strong alkali and chloromethane, reacting and then generating m-methoxytoluene; and (2) mixing a catalyst and a solvent, dropwise adding the m-methoxytoluene for 0.5-2h, dropwise adding tert-butyl chloride for 0.5-2h, then reacting for 3-5h and generating tertiary butyl methoxyl methylbenzene. According to the synthesis method of the musk ambrette, methylanisole (replenishing sodium hydroxide to an aqueous alkaline solution, filtering out sodium chloride and then recycling) is synthesized by m-cresol and chloromethane in the water solution of strong alkali, so that compared with a traditional production technology, the yield is improved, treatment of waste water is reduced, manpower resource is saved, energy consumption is reduced and the synthesis method is safer and more reliable.

Rhenium complexes-catalyzed alkylation of arenes with alkyl halides

Rhenium complexes have been shown to catalyze the alkylation of arenes with alkyl halides. When arenes were reacted with an alkyl chloride in the presence of a catalytic amount of rhenium complexes, such as bromopentacarbonylrhenium(I) [ReBr(CO)5], tricarbonylcyclopentadienylrhenium(I) [Re(C5H5)(CO)3] and decacarbonyldirhenium [Re2(CO)10], alkylation of the arenes proceeded under mild conditions to give a mixture of mono- and dialkyl substituted arenes in moderate-to-good yields.

Synthesis of Substituted Dibenzophospholes. Part 8. Synthesis and Resolution of Atropisomers of a 4,6-Diaryldibenzophosphole

Regiospecific replacement of the 4''- and 6'-nitro groups in a 2,2'',4'',6'-teranitro-m-quaterphenyl by alkoxy groups has been effected in two ways: (i) the dialkali salts of α-oximinoalkanoic acids replaced one nitro group by a hydroxy group; after O-alkylation the other alkoxydenitration was effected by sodium benzaldehyde oxime followed by O-alkylation; (ii) both nitro groups were replaced by treatment with sodium 2,2-dimethoxy-1,2-diphenylethanone oximate followed by acidic hydrolysis, alkaline cleavage, and O-alkylation.From the product, synthetic procedures already developed gave 3,7-di-isopropoxy-5-methoxy-4,6-bis-(4-methoxy-2-methyl)dibenzophosphole 5-oxide, separated by chromatography into one racemic and two meso forms.The thermal interconversion of the three forms was demonstrated and measured.The racemic form was resolved by high-performance liquid chromatography (h.p.l.c.) on a chiral column.

NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 46.1) TRIMETHYLSILYLDIAZOMETHANE: A CONVENIENT REAGENT FOR THE O-METHYLATION OF PHENOLS AND ENOLS

Trimethylsilyldiazomethane reacts smoothly with phenols and enols in methanolic acetonitrile solution in the presence of N,N-diisopropylethylamine to give methyl ethers. KEYWORDS --- trimethylsilyldiazomethane; phenol; enol; O-methylation; methyl ether