83015-25-2

Usage

Uses

Used in Pharmaceutical Industry:
N,N-DiMethyl-3-phenyl-3-(o-tolyloxy)propan-1-aMine is used as a medicinal agent for its stimulant and psychoactive properties, acting as a dopamine and norepinephrine releasing agent. This action affects the central nervous system, leading to increased energy, alertness, and euphoria, which can be beneficial for certain medical conditions.
Used in Recreational Drug Industry:
N,N-DiMethyl-3-phenyl-3-(o-tolyloxy)propan-1-aMine is also used as a recreational drug due to its ability to produce stimulant and psychoactive effects. However, it is important to note that the use of N,N-DiMethyl-3-phenyl-3-(o-tolyloxy)propan-1-aMine for recreational purposes is often regulated and controlled in many jurisdictions due to its potential for abuse and health risks.

Upstream product

• 615-37-2 ortho-methylphenyl iodide 
• 5554-64-3 N,N-dimethyl-3-hydroxy-3-phenylpropylamine 
• 79130-51-1 3-chloro-N,N-dimethyl-3-phenylpropan-1-amine 
• 95-48-7 ortho-cresol 
• 1011-59-2 3-(dimethylamino)-1-phenylpropyl chloride hydrochloride 
• 19578-70-2 benzyl 2-methylphenyl ether 
• 107-99-3 2-(dimethylamino)ethyl chloride 

Downstream Products

• 93982-97-9 N-methyl-3-[(o-methylphenoxy)-3-phenylpropyl]-carbamic acid phenyl ester 

Relevant academic research and scientific papers

AN IMPROVED PROCESS FOR SYNTHESIZING HIGHLY PURE ATOMOXETINE

The present invention relates to a process for the preparation of highly pure atomoxetine of formula (I) and pharmaceutically acceptable salts thereof Formula (I) The present invention also aims at novel processes for the preparation and purification of intermediates involved in the process of the present invention.

PROCESS FOR PREPARING ATOMOXETINE HYDROCHLORIDE

The present invention relates to the process for preparing Atomoxetine hydrochloride which is a selective norepinephrine reuptake inhibitor. Atomoxetine HCl is chemically known as (-)-iV-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride and represented by formula (I). More particularly, the invention relates to crystalline form of N-methyl-3-phenyl-3-(o- tolyloxy) propylamine oxalate (here in after referred as "(±) Atomoxetine Oxalate"), which is an useful intermediate for the synthesis of Atomoxetine hydrochloride.

A process for the preparation of aryloxypropylamines

A process for the preparation of a compound of formula (I), or a salt thereof, both as the as individual isomer and as mixtures thereof, wherein each of A and B is independently aryl or heteroaryl optionally substituted with 1 to 4 substituents; and R and R1, which can be the same or different, are hydrogen, C1-C6 alkyl or an amino-protecting group; comprising the reaction of a compound (II) wherein A and B are as defined above, with a compound (III) wherein each of R and R1 is independently C1-C6 alkyl or an amino-protecting group; and X is a leaving group; in the presence of a basic agent; and, if desired the conversion of a compound (I) to another compound (I); and/or, if desired, the separation of an isomeric mixture of a compound (I) into the individual isomers; and/or, if desired, the conversion of a compound (I) to a salt thereof.

PROCESS FOR THE PREPARATION OF ARYLOXYPROPYLAMINES

A process for preparation of a compound of formula (I), or a salt thereof, both as individual isomer and as mixtures thereof, wherein each of A and B is independently aryl or heteroaryl optionally substituted with 1 to 4 substituents; and R and R1, which can be the same or different, are hydrogen, C1-C6 alkyl or an amino-protecting group; comprising the reaction of a compound (II) wherein A and B are as defined above, with a compound (III) wherein each of R and R1 is independently C1-C6 alkyl or an amino-protecting group; and X is a leaving group; in the presence of a basic agent; and, if desired the conversion of a compound (I) to another compound (I); and/or, if desired, the separation of an isomeric mixture of a compound (I) into the individual isomers; and/or, if desired, the conversion of a compound (I) to a salt thereof.

Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers

Provided is an efficient method for the preparation of 3-aryloxy-3-arylpropylamines, their optical stereoisomers, and pharmaceutically acceptable salts thereof. The process allows for the isolation of 3-aryloxy-3-arylpropylamines in high yield and purity. The present invention further relates to a process for producing fluoxetine, tomoxetine, norfluoxetine, duloxetine, nisoxetine, and their optically enriched (R)— and (S)-enantiomers.

AN EFFICIENT METHOD FOR PREPARING 3-ARYLOXY-3- ARYLPROPYLAMINES AND THEIR OPTICAL STEREOISOMERS

Provided is an efficient method for the preparation of 3-aryloxy-3- arylpropylamines, their optical stereoisomers, and pharmaceutically acceptable salts thereof. The process allows for the isolation of 3-aryloxy-3- arylpropylamines in high yield and purity. The present invention further relates to a process for producing fluoxetine, tomoxetine, norfluoxetine, duloxetine, nisoxetine, and their optically enriched (R)- and (S)-enantiomers.