83015-28-5Relevant articles and documents
Synthesis and Reactivity of Fluoroalkyl Copper Complexes by the Oxycupration of Tetrafluoroethylene
Ohashi, Masato,Adachi, Takuya,Ishida, Naoyoshi,Kikushima, Kotaro,Ogoshi, Sensuke
, p. 11911 - 11915 (2017/09/21)
The copper(I)-mediated generation of -OCF2CF2- moieties by the oxycupration of tetrafluoroethylene (TFE) using either copper aryloxides or alkoxides is disclosed. The key intermediates, 2-aryloxy-1,1,2,2-tetrafluoroethyl and 2-alkoxy
Copper(0)-mediated fluoroalkylation of iodobenzene with 2-bromo-1,1,2,2-tetrafluoroethyl compounds: Investigation on the influence of R substituent on the reactivity of RCF2Cu species
Zhu, Jieming,Ni, Chuanfa,Gao, Bing,Hu, Jinbo
, p. 139 - 147 (2015/03/04)
We have made a systematic investigation on the copper(0)-mediated tetrafluoroethylenation of iodobenzene with structurally diverse 2-bromo-1,1,2,2-tetrafluoroethyl compounds. A comparison of this reaction with 1,2,2-trifluoro-1-phenylethylation and the known functionalized difluoroalkylation demonstrates that the substituent R of α,α-difluoroalkyl copper species RCF2Cu plays a crucial role on their reactivity, which is believed to be useful for the development of new fluoroalkylation reactions under the promotion of transition metals.
A practical synthesis of aryl tetrafluoroethyl ethers via the improved reaction of phenols with 1,2-dibromotetrafluoroethane
Li, Jianqing,Qiao, Jennifer X.,Smith, Daniel,Chen, Bang-Chi,Salvati, Mark E.,Roberge, Jacques Y.,Balasubramanian, Balu N.
, p. 7516 - 7519 (2008/03/14)
An efficient and practical synthesis of various aryl tetrafluoroethyl ethers by the reaction of phenols with 1,2-dibromotetrafluoroethane and the subsequent reduction with zinc dust was described. The nucleophilic substitution of 1,2-dibromotetrafluoroethane with phenols initiated by bromophilic attack was improved by using Cs2CO3 as a base and DMSO as a solvent.