83019-13-0Relevant academic research and scientific papers
STEREOSELECTIVE SYNTHESES OF SOLENOPSIN A AND B
Matsumura, Yasushi,Maruoka, Keiji,Yamamoto, Hisashi
, p. 1929 - 1932 (1982)
Effective and convenient syntheses of solenopsin A and B have been developed which involve the Beckmann rearrangement-alkylation reaction promoted by organoaluminum reagents and a new stereoselective reduction of imino functional group.
Two efficient four-step routes to marine toxin tanikolide
Chen, Qingshou,Deng, Haibing,Zhao, Jingrui,Lu, Yong,He, Mingyuan,Zhai, Hongbin
, p. 8390 - 8393 (2005)
We have presented two facile four-step syntheses of (±)-tanikolide from ethyl 2-oxocyclopentanecarboxylate. The overall chemical yields of the two sequences reached as high as 76 and 85%, respectively. The first strategy involved alkylation, Baeyer-Villiger reaction, saponification, and reduction/lactonization. The second approach for synthesizing tanikolide took advantage of the same intermediate, the alkylated ketoester 2, which was converted to the target molecule in such three steps as deethoxycarbonylation, hydroxymethylation, and Baeyer-Villiger reaction. Our strategies are advantageous because of their high yields and suitability for the preparation of 1 in multigram or larger quantities.
Organoaluminum-Promoted Beckmann Rearrangement of Oxime Sulfonates
Maruoka, Keiji,Miyazaki, Tohru,Ando, Mamoru,Matsumura, Yasushi,Sakane, Soichi,et al.
, p. 2831 - 2843 (2007/10/02)
The Beckmann rearrangement of oxime sulfonates with simultaneous nucleophilic trapping of the intermediary iminocarbocation by organoaluminum reagents is described.This process provides a new and highly efficient route to imino thioethers, imino selenoethers, imino nitriles, and α-alkylated amines starting from oxime sulfonates by the use of dialkylaluminum thiolates, selenolates, diethylaluminum chloride-trimethylsilyl cyanide, and trialkylaluminum-diisobutylaluminum hydride systems, respectively.The present organoaluminum-promoted Beckmann rearrangement of oxime sulfonates has been successfully applied to the synthesis of naturally occuring alkaloids, pumiliotoxin C and solenopsin A and B, in stereoselective fashion.Moreover, α,α-dialkylation of amines can be realized by the successive treatment of oxime sulfonates with trialkylaluminum followed by allylic or propargylic Grignard reagents in synthetically useful yields.
