83049-49-4Relevant academic research and scientific papers
Synthesis of tetrahydroisoquinoline derivatives and evaluation of their anti-breast cancer activity
Zhang,Yu,Ding,He,Zou
, p. 1430 - 1433 (2016)
Four novel tetrahydroisoquinoline derivatives 1–4 were synthesized and characterized by IR, 1H NMR, HRMS, and single crystal X-ray crystallography. Anticancer effect of the products were studied on five human breast cancer cell lines including
Facile one-pot synthesis of novel ortho-aminocarbonitriles and dicyanoanilines fused to heterocycles via pseudo four-component reactions
Mojtahedi, Mohammad M.,Pourabdi, Ladan,Abaee, M. Saeed,Jami, Hamed,Dini, Masoud,Halvagar, Mohammad R.
, p. 1699 - 1705 (2016/03/08)
1-Methylpiperidin-4-one and its sulfur and oxygen analogues undergo individual facile pseudo four-component reactions with two folds of malononitrile and various aldehydes by using ultrasonic irradiation and deficient quantities of pyrrolidine. As a conse
A SPONTANEOUS RING CLOSURE REACTION AS A NEW ROUTE TO ISOQUINOLINE DERIVATIVES
Andresen, Ole Riis,Pedersen, Erik B.
, p. 1467 - 1471 (2007/10/02)
A spontaneous reaction takes place between benzaldehydes, malononitrile and N-methyl-4-piperidone to yield the compounds 1a-i which can be aromatized to the new dicyano-1,2,3,4-tetrahydroisoquinolinamines 2a-e.Tetrahydro-2,7-naphtyridines 3a,b were also i
