831222-65-2Relevant articles and documents
cis-Semihydrogenation of alkynes with amine borane complexes catalyzed by gold nanoparticles under mild conditions
Vasilikogiannaki, Eleni,Titilas, Ioannis,Vassilikogiannakis, Georgios,Stratakis, Manolis
supporting information, p. 2384 - 2387 (2015/02/05)
Supported gold nanoparticles catalyze the semihydrogenation of alkynes to alkenes with ammonia borane or amine borane complexes in excellent yields and under mild conditions. Internal alkynes provide cis-alkenes, making this protocol an attractive alternative of the classical Lindlar's hydrogenation.
Amidobenzothiazoles And Process For The Preparation Thereof
-
, (2013/12/04)
The present invention provides a compound of general formulae A useful as potential anti-cancer agents against human cancer cell lines and a process for the preparation thereof. Where in R, R1, R2═H, alkyl, alkoxy, halo, haloalkyl, halomethoxy, nitro and G= Where in R, R1, R2═H, alkyl, alkoxy, halo, haloalkyl, halomethoxy, nitro and G=
Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents
Kamal, Ahmed,Bharathi, E. Vijaya,Reddy, J. Surendranadha,Ramaiah, M. Janaki,Dastagiri,Reddy, M. Kashi,Viswanath,Reddy, T. Lakshminarayan,Shaik, T. Basha,Pushpavalli,Bhadra, Manika Pal
experimental part, p. 691 - 703 (2011/03/22)
A series of new 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydro quinazolinone hybrids with different linker architectures have been designed and synthesized. These compounds have been evaluated for their anticancer activity. One of the compounds 4c amongst this series has shown promising anticancer activity. Further some detailed biological assays relating to the cell cycle aspects and tubulin depolymerization activity have been examined with a view to understand the mechanism of action of this conjugate.
Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/ isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents
Kamal, Ahmed,Surendranadha Reddy,Janaki Ramaiah,Dastagiri,Vijaya Bharathi,Ameruddin Azhar,Sultana, Farheen,Pushpavalli,Pal-Bhadra, Manika,Juvekar, Aarti,Sen, Subrata,Zingde, Surekha
scheme or table, p. 3924 - 3937 (2010/09/11)
A series of 3,5-diaryl-isoxazoline/isoxazole linked pyrrolo[2,1-c][1,4] benzodiazepine (PBD) conjugates were prepared. These conjugates showed potent anticancer activity with GI50 values in the range of 0.1-3.6 μM. Some of these PBD conjugates (6a-c) with promising anticancer activity were further investigated on the cell cycle distribution. Moreover, these PBD conjugates exhibited G0/G1 arrest, enhancement in the levels of p53 protein as well as mitochondrial-mediated intrinsic pathway, leading to release of cytochrome c, activation of caspase-3, cleavage of PARP and subsequent apoptotic cell death. Hence these PBD conjugates with 6a being the most potent one could be be taken up for preclinical studies either alone or in combination with existing therapies. New class of 3,5-diaryl-isoxazoline/isoxazole- pyrrolobenzodiazepine conjugates were prepared and evaluated for their anticancer activity. Further, some of the biological assays related to mechanism aspects were also carried out.
Total synthesis of ovalifoliolatin B, acerogenins A and C
Kishore Kumar,Natarajan, Amarnath
, p. 2103 - 2105 (2008/09/18)
A short and concise route for the synthesis of ovalifoliolatin B, a highly strained macrocyclic diaryl ether heptanoid natural product that also provides quick access to acerogenins A and C natural products has been reported.
Synthesis of substituted styrenes and stilbenes mediated by palladium on zirconia
Borate, Hanumant B.,Dumbre, Deepa K.,Wakharkar, Radhika D.,Choudhary, Vasant R.
experimental part, p. 495 - 499 (2009/04/06)
Palladium on zirconia has been found to be an effective catalyst for the synthesis of various substituted styrenes and stilbenes, including biologically active natural products, by reaction of aryl halides with olefins.
The kulinkovich reaction in the synthesis of constrained N,N-dialkyl neurotransmitter analogues
Faler, Catherine A.,Joullie, Madeleine M.
, p. 1987 - 1990 (2008/02/02)
An intermolecular Ti(IV)-mediated cyclopropanation reaction has been used to synthesize substituted 2-phenylcyclopropylamines and constrained analogues of the neurotransmitters histamine and tryptamine. Many hydroxy- and methoxy-substituted phenylcyclopropylamines are known to inhibit monoamine oxidase and have been shown to mimic hallucinogens. These compounds were made in 1 to 5 steps from readily available starting materials.
Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines
Simoni, Daniele,Grisolia, Giuseppina,Giannini, Giuseppe,Roberti, Marinella,Rondanin, Riccardo,Piccagli, Laura,Baruchello, Riccardo,Rossi, Marcello,Romagnoli, Romeo,Invidiata, Francesco Paolo,Grimaudo, Stefania,Jung, M. Katherine,Hamel, Ernest,Gebbia, Nicola,Crosta, Lucia,Abbadessa, Vincenzo,Di Cristina, Antonietta,Dusonchet, Luisa,Meli, Maria,Tolomeo, Manlio
, p. 723 - 736 (2007/10/03)
Two new series of combretastatin (CA-4) analogues have been prepared. The alkenyl motif of CA-4 was replaced either by a five-membered heterocyclic (isoxazoline or isoxazole) or by a six-membered ring (pyridine or benzene). The new compounds have been evaluated for their effects on tubulin assembly and for cytotoxic and apoptotic activities. Five compounds (18b, 20a, 21a, 34b, and 35b) demonstrated an attractive profile of cytotoxicity (IC50 1 μM) and apoptosis-inducing activity but poor antitubulin activity. The isoxazoline derivatives 18b, 20a, and 21a, demonstrated potent apoptotic activity different from that of natural CA-4. Their ability to block most cells in the G2 phase suggests that these compounds could act on targets different from the mitotic spindle. This would indicate activation of both the intrinsic and the extrinsic apoptotic pathways. The data suggest unambiguously that structural alteration of the stilbene motif of CA-4 can be extremely effective in producing potent apoptosis-inducing agents.
