83148-65-6

Basic information

• Product Name: 5-benzamido-2-methyl-4-oxo-6-phenylhexanoylproline
• Synonyms: 5-benzamido-2-methyl-4-oxo-6-phenylhexanoylproline
• CAS NO: 83148-65-6
• Molecular Formula: C₂₅H₂₈N₂O₅
• Molecular Weight: 436.5002
• Mol File: 83148-65-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 732.3°Cat760mmHg
• Flash Point: 396.7°C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 1.64E-22mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 5-benzamido-2-methyl-4-oxo-6-phenylhexanoylproline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-benzamido-2-methyl-4-oxo-6-phenylhexanoylproline(83148-65-6)
• EPA Substance Registry System: 5-benzamido-2-methyl-4-oxo-6-phenylhexanoylproline(83148-65-6)

Safety Data

• Hazardous Substances Data: 83148-65-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C25H28N2O5/c1-17(24(30)27-14-8-13-21(27)25(31)32)15-22(28)20(16-18-9-4-2-5-10-18)26-23(29)19-11-6-3-7-12-19/h2-7,9-12,17,20-21H,8,13-16H2,1H3,(H,26,29)(H,31,32)/t17-,20+,21+/m1/s1

Upstream product

• 83084-78-0 (R)-4-(4-Benzyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-methyl-4-oxo-butyric acid methyl ester 
• 83084-78-0 4-(4-Benzyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-methyl-4-oxo-butyric acid methyl ester 
• 83084-79-1 (R)-5-Benzoylamino-2-methyl-4-oxo-6-phenyl-hexanoic acid methyl ester 
• 83084-79-1 methyl 5-benzamido-2-methyl-4-oxo-6-phenylhexanoate 
• 82291-89-2 (R)-5-Benzoylamino-2-methyl-4-oxo-6-phenyl-hexanoic acid 
• 83084-80-4 5-benzamido-2-methyl-4-oxo-6-phenylhexanoic acid 
• 59700-83-3 3-Carbomethoxybutyryl chloride 
• 22644-27-5 (R)-methylsuccinic acid dimethyl ester 
• 3641-51-8 2-(R)-methylsuccinic acid 
• 498-21-5 2-methylbutanedioic acid 
• 83084-81-5 5-benzamido-2(R)-methyl-4-oxo-6-phenylhexanoyl-L-proline 
• 21307-96-0 methyl 2-methylsuccinate 

Relevant articles and documents

Derivatives of the potent angiotensin converting enzyme inhibotor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline: Effect of changes at positions 2 and 5 of the hexanoic acid portion

Several derivatives of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline (1) were synthesized and tested for converting enzyme inhibition activity and blood pressure lowering effects in rats. One compound, 5(S)-benzamido-2(R)-methyl-4-oxo-6-phenylhexanoyl-L-proline (2a), had an I50 against angiotensin converting enzyme of 1.0 x 10-9 M and is the most potent inhibitor prepared thus far in this class of compounds. Testing of 2a orally at 30 mg/kg for inhibition of the angiotensin I induced blood pressure increase in conscious normotensive rats gave 100% inhibition that required 143 min before the angiotensin I blood pressure response returned to 70% of the pretreatment control response. In the conscious renal hypertensive rat, 2a given orally at a dose of 3 mg/kg caused a lowering of blood pressure that reached its maximum of 40 mmHg 8 h following drug administration.