83177-91-7Relevant academic research and scientific papers
Regio- and Stereoselective Alkylation of a Pyrrolidinic System: Structural and Conformational Studies by High Field NMR Techniques
Schaefer, M.,Faller, P.,Nicole, D.
, p. 108 - 111 (2007/10/02)
A new merocyanine was prepared by addition of the pyrrolidine enamine of N-ethoxycarbonylpyrrolidine-3-one to 1-octyne-3-one.This addition was regioselective (with an unexpected C-4 alkylation of the pyrrolidinone-3-enamine) and stereospecific (exclusively trans addition to the triple bond).The structure and conformational equilibrium were studied by high resolution proton magnetic resonance (NOE and variable temperature effects).Activation parameters ΔH*, ΔS* and ΔG* are given, and the behaviour on protonation examined.
1-Pyrrole- and 1-pyrrolidine-carboxylic acid derivatives and process for preparing the same
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, (2008/06/13)
1-Pyrrole- and 1-pyrrolidine-carboxylic acid derivatives corresponding to the general formula: STR1 in which R represents an alkyl radical having from 1 to 4 carbon atoms, preferably ethyl, and Am represents a group: STR2 wherein R1 represents a 3-oxo-alkyl radical STR3 or a 3-oxo-alkenyl radical STR4 and R2 represents hydrogen or R1 and R2, when they are identical, each represent hydrogen, STR5 R3 representing an alkyl radical having from 1 to 5 carbon atoms with the proviso that when R1 and R2 are simultaneously hydrogen, Am represents the group A. The novel derivatives are useful as intermediates for synthetizing azaprostaglandines.
