83196-67-2Relevant articles and documents
The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity
Espinoza, Jaime A.,Zisi, Asimina,Kanellis, Dimitris C.,Carreras-Puigvert, Jordi,Henriksson, Martin,Hühn, Daniela,Watanabe, Kenji,Helleday, Thomas,Lindstr?m, Mikael S.,Bartek, Jiri
, p. 773 - 789 (2019/07/18)
Pharmacological inhibition of ribosome biogenesis is a promising avenue for cancer therapy. Herein, we report a novel activity of the FDA-approved antimalarial drug amodiaquine which inhibits rRNA transcription, a rate-limiting step for ribosome biogenesi
