83199-47-7 Usage
Description
Cholesterol-d7 is intended for use as an internal standard for the quantification of cholesterol by GC- or LC-MS. Cholesterol is a major sterol produced in mammalian cells that is required for cell viability and proliferation. It is a component of mammalian cell membranes that interacts with membrane phospholipids, sphingolipids, and proteins to influence their behavior. Cholesterol is a precursor of steroid hormones, bile acids, and the active form of vitamin D. Impaired cholesterol homeostasis is related to development of various diseases including fatty liver, diabetes, gallstones, dyslipidemia, atherosclerosis, heart attack, and stroke.
Chemical Properties
White to Off-White Solid
Uses
Different sources of media describe the Uses of 83199-47-7 differently. You can refer to the following data:
1. Cholesterol-d7 is a labelled Cholesterol (C432501). Cholesterol-d7 is the principal sterol of the higher animals. Cholesterol-d7 was found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Cholesterol-d7 is the main constituent of gallstones. Cholesterol-d7 can be used as a practical tracer for studies of cholesterol metabolism in humans.
2. Labelled Cholesterol (C432501). Cholesterol is the principal sterol of the higher animals. Cholesterol was found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Cholesterol is the main constituent of gallstones.
3. Labelled Cholesterol can be used as a practical tracer for studies of cholesterol metabolism in humans
Check Digit Verification of cas no
The CAS Registry Mumber 83199-47-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,1,9 and 9 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 83199-47:
(7*8)+(6*3)+(5*1)+(4*9)+(3*9)+(2*4)+(1*7)=157
157 % 10 = 7
So 83199-47-7 is a valid CAS Registry Number.
InChI:InChI=1/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1/i1D3,2D3,18D
83199-47-7Relevant articles and documents
Synthesis of [25, 26, 26, 26, 27, 27, 27-d7]-cholesterol
Chu, Guo-Hua,Li, Pui-Kai
, p. 773 - 779 (2000)
An efficient synthesis of [25, 26, 26, 26, 27, 27,27-d7]-cholesterol 1, a useful tool for the measurement of cholesterol absorption, is described. Commercially available stigmasterol is converted into the known aldehyde 2 which was then transformed to the d7-cholesterol 1 through a reaction sequence of 8 steps in an overall yield of 22.5%. Copyright
