Synthesis of [25, 26, 26, 26, 27, 27, 27-d7]-cholesterol

Article abstract of DOI:10.1002/1099-1344(200007)43:8<773::AID-JLCR361>3.0.CO;2-G

An efficient synthesis of [25, 26, 26, 26, 27, 27,27-d₇]-cholesterol 1, a useful tool for the measurement of cholesterol absorption, is described. Commercially available stigmasterol is converted into the known aldehyde 2 which was then transformed to the d₇-cholesterol 1 through a reaction sequence of 8 steps in an overall yield of 22.5%. Copyright