83253-35-4Relevant academic research and scientific papers
Electrochemical Oxidative Regioselective C-H Cyanation of Imidazo[1,2-a]pyridines
Cui, Ting,Zhan, Yanling,Dai, Changhui,Lin, Jun,Liu, Ping,Sun, Peipei
, p. 15897 - 15905 (2021/03/01)
Electrochemical oxidative regioselective C-H cyanation of imidazo[1,2-a]pyridines was developed using readily available TMSCN as the cyano source. The KH2PO4/K2HPO4buffer was essential for this transformation. This protocol was compatible with a broad range of substituted imidazo[1,2-a]pyridines and provided the C3 cyanated products in moderate to excellent yields.
Copper- A nd DMF-mediated switchable oxidative C-H cyanation and formylation of imidazo[1,2-: A] pyridines using ammonium iodide
Ji, Fanghua,Jiang, Guangbin,Li, Xuan,Liu, Meichen,Wang, Shoucai,Zang, Jiawang
, p. 9100 - 9108 (2020/11/27)
The cyanation and formylation of imidazo[1,2-a]pyridines were developed under copper-mediated oxidative conditions using ammonium iodide and DMF as a nontoxic combined cyano-group source and DMF as a formylation reagent. Mechanistic studies indicate that the cyanation of imidazo[1,2-a]pyridines proceeds through a two-step sequence: Initial iodination and then cyanation. The cyanation has a broad substrate scope and high functional group tolerance, and can be safely conducted on a gram scale. A novel copper-mediated formylation using the widely available DMF as the formylation reagent and environmentally friendly molecular oxygen as the oxidant has also been developed. This protocol also provided a convenient approach for the synthesis of clinically used saripidem. This journal is
Investigation on the effects of antimicrobial imidazo[2,1-b]Thiazole derivatives on the genitourinary microflora
Morigi, Rita,Vitali, Beatrice,Prata, Cecilia,Palomino, Rogers A. ?.,Graziadio, Alessandra,Locatelli, Alessandra,Rambald, Mirella,Leoni, Alberto
, p. 311 - 319 (2018/05/17)
Background: Fused five-membered heterocyclic rings containing bridgehead nitrogen atom are particularly versatile in the field of medicinal chemistry because of their different biological activities. Among them, the imidazo[2,1-b]thiazole is an attractive
