83256-18-2Relevant academic research and scientific papers
Synthetic Strategies toward the Synthesis of 2,4-Dimethoxypyrrolopyrimidine
Cupps, Thomas L.,Wise, Dean S.,Townsend, Leroy B.
, p. 1060 - 1064 (2007/10/02)
Two approaches to prepare 2,4-dimethoxypyrrolopyrimidine (1) are described. 2,4-Dimethoxy-6-methyl-5-nitropyrimidine (2) was converted to 6-(cyanomethyl)-2,4-dimethoxy-5-nitropyrimidine (6) in two steps.Subsequent catalytic hydrogenation of 6 produced 1.In a second approach, 2 was formylated, giving rise to 6--2,4-dimethoxy-5-nitropyrimidine (7).Hydrogenation of 7 resulted in the formation of 1.Reduction of 2 provided 5-amino-2,4-dimethoxy-6-methylpyrimidine (10).Reaction of compound 10 with triethyl orthoformate produced 2,4-dimethoxy-5--6-methylpyrimidine (11).Reaction of 11 with lithium diisopropylamide gave 2,4-dimethoxy-5-isocyano-6-methylpyrimidine (12).
REACTION OF DIMETHYLFORMAMIDE DIMETHYLACETAL WITH METHYLPYRIMIDINES
Prikazchikova, L. P.,Khutova, B. M.,Cherkasov, V. M.
, p. 746 - 748 (2007/10/02)
The reaction of dimethylformamide dimethylacetal with methylpyrimidines and methyltriazines was studied, and β-dimethylaminovinylpyrimidines and β-dimethylaminovinyltriazines were obtained.It is shown that electron-acceptor substituents facilitate the rea
