832735-41-8

Basic information

• Product Name: 4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl
• Synonyms: 4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl;1-Boc-4-(5-bromopyrimidin-2-yloxy)piperidine;tert-Butyl 4-((5-bromopyrimidin-2-yl)oxy)piperidine-1-carboxylate
• CAS NO: 832735-41-8
• Molecular Formula: C₁₄H₂₀BrN₃O₃
• Molecular Weight: 358.234
• Mol File: 832735-41-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 451.6 °C at 760 mmHg
• Flash Point: 226.9 °C
• Appearance: /
• Density: 1.394 g/cm³
• Vapor Pressure: 2.4E-08mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl(832735-41-8)
• EPA Substance Registry System: 4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl(832735-41-8)

Safety Data

• Hazardous Substances Data: 832735-41-8(Hazardous Substances Data)

Usage

General Description

4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl is a chemical compound with the molecular formula C14H20N4O3Br. It is a piperidine derivative containing a carboxylic acid and tert-butyl functional group. 4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl is utilized in the field of medicinal chemistry and drug development, where it may serve as a building block for the synthesis of various pharmaceutical agents. Its unique structure and functional groups make it a valuable intermediate for the production of diverse bioactive compounds. Additionally, its bromopyrimidine moiety may impart specific biological activity or target engagement in the resulting molecules, making it a promising scaffold for the development of novel therapeutics.

InChI:InChI=1/C14H20BrN3O3/c1-14(2,3)21-13(19)18-6-4-11(5-7-18)20-12-16-8-10(15)9-17-12/h8-9,11H,4-7H2,1-3H3

Upstream product

• 32779-36-5 5-Bromo-2-chloropyrimidine 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Downstream Products

• 832735-42-9 2-(1-tert-butoxycarbonylpiperidine-4-yloxy)-5-(4-cyanophenyl)pyrimidine 
• 1189551-44-7 t-butyl 4-[(5-phenylpyrimidin-2-yl)oxy]piperidine-1-carboxylate 
• 1189551-86-7 t-butyl 4-[(5-pyridin-2-ylpyrimidin-2-yl)oxy]piperidine-1-carboxylate 

Relevant articles and documents

INHIBITORS OF MUTANT ISOCITRATE DEHYDROGENASES AND COMPOSITIONS AND METHODS THEREOF

The invention provides novel chemical compounds useful for treating cancer, or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.

HETEROARYLOXY NITROGENOUS SATURATED HETEROCYCLIC DERIVATIVE

Provided are compounds of a formula (I) and their pharmaceutically-acceptable salts: wherein X1, X2 and X3 each independently represent N or CH; W represents the following formula (II): or the following formula (III): Y represents a group of a formula (IV): The compounds have a histamine-H3 receptor antagonistic or inverse-agonistic activity and are useful for remedy and/or prevention of obesity, diabetes, hormone secretion disorders, sleep disorders, etc.

TREATMENT OF TREMOR WITH HISTAMINE H3 INVERSE AGONISTS OR HISTAMINE H3 ANTAGONISTS

Histamine H3 inverse agonists or histamine H3 antagonists are useful, alone or in combination with a neuroleptic agent, for treating or preventing movement disorders, including tremor, such as essential tremor, and tremor associated with Parkinson’s disea