832735-56-5

Basic information

• Product Name: 4-broMo-2-(difluoroMethoxy)pyridine
• Synonyms: 4-broMo-2-(difluoroMethoxy)pyridine;Pyridine,4-bromo-2-(difluoromethoxy)-
• CAS NO: 832735-56-5
• Molecular Formula: C₆H₄BrF₂NO
• Molecular Weight: 224.0028664
• Mol File: 832735-56-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 198.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.670±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0?+-.0.10(Predicted)
• CAS DataBase Reference: 4-broMo-2-(difluoroMethoxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-broMo-2-(difluoroMethoxy)pyridine(832735-56-5)
• EPA Substance Registry System: 4-broMo-2-(difluoroMethoxy)pyridine(832735-56-5)

Safety Data

• Hazardous Substances Data: 832735-56-5(Hazardous Substances Data)

Usage

General Description

4-bromo-2-(difluoromethoxy)pyridine is a chemical compound with the molecular formula C6H4BrF2NO. It is a pyridine derivative that contains a bromine atom and two fluorine atoms, as well as a methoxy group. 4-broMo-2-(difluoroMethoxy)pyridine is often used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its ability to act as a nucleophile and form carbon-carbon bonds. It is also used in the development of OLEDs (organic light-emitting diodes) and as an intermediate in the production of various chemical compounds. Additionally, 4-bromo-2-(difluoromethoxy)pyridine has been studied for its potential biological activities, such as its use as a potential antifungal agent.

Upstream product

• 36953-37-4 4-bromo-2(1H)-pyridinone 
• 1895-39-2 sodium chlorodifluoroacetate 
• 76-04-0 2-chloro-2,2-difluoroacetic acid 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 

Downstream Products

• 1628116-87-9 2-difluoromethoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine 
• 1227184-45-3 5-(2-(Difluoromethoxy)pyridin-4-yl)-5-(3-(3-fluoropropoxy)phenyl)-5H-pyrrolo[3,4-b]pyridin-7-amine 

Relevant articles and documents

Chemoselective N- And O-Difluoromethylation of 2-Pyridones, Isoquinolinones, and Quinolinones with TMSCF2Br

An operationally simple protocol for direct N- and O-difluoromethylation of 2-pyridones, quinolinones, and isoquinolinones using commercially available TMSCF2Br is disclosed. The chemoselectivity is modulated by simple variations in temperature, solvent,

5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES FOR TREATING NEUROLOGICAL AND NEURODEGENERATIVE DISEASES

The present invention provides, in part, compounds of Formula (I): or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N- oxide, wherein: R1, R2, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4- associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.

SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS

The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, R4, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders, including inflammatory and renal disorders.