83277-24-1

Upstream product

• 120100-50-7 methyl-3-bromomethyl-2,4-dichlorobenzoate 
• 83277-23-0 2,4-Dichloro-3-methyl-benzoic acid 
• 118-69-4 2,6-dichlorotoluene 
• 67-56-1 methanol 

Downstream Products

• 83277-23-0 2,4-Dichloro-3-methyl-benzoic acid 
• 120100-50-7 methyl-3-bromomethyl-2,4-dichlorobenzoate 
• 196819-99-5 methyl 2,4-dichloro-3-formylbenzoate 

Relevant academic research and scientific papers

Substituted benzoyl-pyrazole compounds and application thereof in agriculture

The invention provides substituted benzoyl-pyrazole compounds and an application thereof in agriculture. Specifically, the invention provides the compounds represented by a formula (I) and a preparation method thereof. the invention discloses aompositions

Sulfone-Based Probes Unraveled Dihydrolipoamide S-Succinyltransferase as an Unprecedented Target in Phytopathogens

Target validation of current drugs remains the major challenge for target-based drug discovery, especially for agrochemical discovery. The bactericide 0 represents a novel lead structure and has shown potent efficacy against those diseases that are extremely difficult to control, such as rice bacterial leaf blight. However, no detailed target analysis of this bactericide has been reported. Here, we developed a panel of 0-derived probes 1?6, in which a conservative modification (alkyne tag) was introduced to keep the antibacterial activity of 0 and provide functionality for target identification via click chemistry. With these cell-permeable probes, we were able to discover dihydrolipoamide S-succinyltransferase (DLST) as an unprecedented target in living cells. The probes showed good preference for DLST, especially probe 1, which demonstrated distinct selectivity and reactivity. Also, we reported 0 as the first covalent DLST inhibitor, which has been used to confirm the involvement of DLST in the regulation of energy production.

ROR NUCLEAR RECEPTOR MODULATORS

The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological conditions.

COMPOUNDS HAVING ACTIVITY AT 5HT2C RECEPTOR AND USES THEREOF

Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein R1 is halogen, cyano, C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkyloxy, C1-6alkoxy, C1 6alkylthio, hydroxy, amino, mono or di C1 6alkylamino, an N-linked 4 to 7 memb

Substituted 2-benzoyl-cyclohexan-1,3-diones with herbicidal effect

The invention relates to 2-benzoylcyclohexane-1,3-diones of the formula I where R1, R2are each hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alkynyl, —OR5, —OCOR6, —OSOsu

Substituted 2-(3-alkenyl-benzoyl)-cyclohexane-1,3-diones

The invention relates to 2-(3-alkenylbenzoyl)cyclohexane-1,3-diones of the formula I where the variables have the following meanings: R1, R2are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alk

Substituted 4-benzoylpyrazoles

PCT No. PCT/EP97/07210 Sec. 371 Date Jun. 23, 1999 Sec. 102(e) Date Jun. 23, 1999 PCT Filed Dec. 19, 1997 PCT Pub. No. WO98/29392 PCT Pub. Date Jul. 9, 1998The invention relates to 4-benzoylpyrazoles of the formula I and their agriculturally useful salts

Substituted 4-(3-alkenylbenzoyl)pyrazoles

PCT No. PCT/EP98/02433 Sec. 371 Date Nov. 2, 1999 Sec. 102(e) Date Nov. 2, 1999 PCT Filed May 5, 1998 PCT Pub. No. WO98/50366 PCT Pub. Date Nov. 12, 19984-(3-Alkenylbenzoyl)pyrazoles of the formula I and agriculturally useful salts thereof; processes for preparing the compounds of the formula I; compositions comprising them; and the use of these derivatives or of compositions comprising them for controlling undesirable plants.