83277-30-9

Usage

InChI:InChI=1/C7H13NO3/c1-5(2)8-3-6(4-9)11-7(8)10/h5-6,9H,3-4H2,1-2H3

Upstream product

• 584-08-7 potassium carbonate 
• 75-31-0 isopropylamine 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 124-38-9 carbon dioxide 
• 50666-68-7 3-isopropylamino-2-hydroxy-1-chloropropane 
• 6452-57-9 1,2-dihydroxy-3-isopropylaminopropane 
• 616-38-6 carbonic acid dimethyl ester 
• 99726-37-1 N-(2-propenyl)-1-methylethanamine hydrobromide 
• 99726-38-2 5-(iodomethyl)-3-isopropyloxazolidin-2-one 
• 78723-67-8 5-bromomethyl-3-(1-methylethyl)oxazolidin-2-one 
• 95360-67-1 (R,S)-5-acetoxymethyl-3-isopropyl-oxazolidin-2-one 

Downstream Products

• 116908-87-3 Acetic acid (R)-3-isopropyl-2-oxo-oxazolidin-5-ylmethyl ester 
• 68430-29-5 (S)-5-hydroxymethyl-3-(methylethyl)oxazolidinone 
• 116809-23-5 Propionic acid (R)-3-isopropyl-2-oxo-oxazolidin-5-ylmethyl ester 
• 525-66-6 propranolol 
• 68430-37-5 (+)-(R)-5-(hydroxymethyl)-3-isopropyloxazolidin-2-one 
• 1182705-22-1 C₁₃H₁₇NO₅S 
• 1612878-78-0 5-(4-benzhydryl-piperazin-1-ylmethyl)-3-isopropyl-oxazolidin-2-one 
• 194732-25-7 N-{4-amino-2-[3-(1-methylethyl)-2-oxo-oxazolidin-5-ylmethoxy]pyridin-3-yl}-2,4-dimethoxybenzamide 
• 194732-44-0 N-{4-amino-6-[3-(1-methylethyl)-2-oxo-oxazolidin-5-ylmethoxy]pyridin-3-yl}-2,4-dimethoxybenzamide 
• 194732-27-9 5-[2-(2,4-Dimethoxy-phenyl)-1H-imidazo[4,5-c]pyridin-4-yloxymethyl]-3-isopropyl-oxazolidin-2-one 
• 194732-46-2 5-[2-(2,4-Dimethoxy-phenyl)-1H-imidazo[4,5-c]pyridin-6-yloxymethyl]-3-isopropyl-oxazolidin-2-one 
• 116907-39-2 Butyric acid (R)-3-isopropyl-2-oxo-oxazolidin-5-ylmethyl ester 

Relevant academic research and scientific papers

Switchable synthesis of cyclic carbamates by carbon dioxide fixation at atmospheric pressure

The base-promoted switchable synthesis of five- and six-membered cyclic carbamates using atmospheric pressure carbon dioxide as the C1 source was developed. The chemoselectivity of products was simply controlled by changing bases and solvents. The reaction proceeds effectively under mild conditions, affording valuable cyclic carbamates. Experimental results and DFT studies revealed the reaction mechanism.

Bioisosteric replacement and related analogs in the design, synthesis and evaluation of ligands for muscarinic acetylcholine receptors

Previous structure-activity relationship studies involving a series of lactone-based muscarinic ligands identified a lead compound containing a diphenylmethylpiperazine moiety (4; IC50 = 340 nM). The purpose of the present work is to investigate 1,3-benzodioxoles, 4,4-diethyl substituted tetrahydrofurans, 5-substituted oxazolidinones and chromones as bioisosteric replacements for the lactone ring in a novel series of muscarinic ligands. The approach provided compounds with improved % inhibition values and identified a non-selective muscarinic ligand with an IC50 value of 280 nM. The structure-activity relationship for this new series will be discussed. Selected compounds were evaluated in preliminary assays for subtype selectivity and were found to be non-selective.

MANUFACTURE OF BISOPROLOL AND INTERMEDIATES THEREFOR

A process for preparing bisoprolol comprises reacting oxazolidinone sulphonate with 4-hydroxybenzylaldehyde to form oxazolidinone benzaldehyde, forming oxazolidone benzylalcohol from oxazolidone benzaldehyde, and subsequently reacting oxazolidinone benzylalcohol with isopropyl oxitol to form bisoprolol base. Oxazolidone sulphonate and oxazolidone benzaldehyde are novel intermediates.

Synthesis of 'A' Ring Isomazole Oxypropanolamines via Hydrolysis of 1H-Imidazopyridine Oxazolidin-2-ones

The hydrolysis of oxazolidin-2-one 15, under forcing conditions, gives the oxypropanolamine 7 and 4,5-dihydro-1H-imidazopyridin-4-ones (17-19) and may occur by a BAL mechanism, involving intramolecular nucleophilic attack by pyridyl nitrogen.

Dihydro azino isoquinolines

The invention provides novel 1,5-substituted isoquinoline derivatives of formula I which are useful in the treatment of hypertension.