83326-52-7

Upstream product

• 83326-48-1 6-Imino-1-phenyl-2-thiophen-2-yl-1,6-dihydro-pyrimidine-5-carbonitrile 
• 100-63-0 phenylhydrazine 
• 36668-22-1 N′-phenylthiophene-2-carbohydrazide 
• 616-47-7 1-methyl-1H-imidazole 
• 36756-95-3 N-phenyl-C-(2-thienyl)formohydrazidoyl chloride 

Relevant academic research and scientific papers

A formal [3+2] cycloaddition reaction of: N -methylimidazole as a masked hydrogen cyanide: Access to 1,3-disubstitued-1 H -1,2,4-triazoles

N-Methylimidazole (NMI) can act as a masked HCN in the synthesis of 1,3-disubstitued-1H-1,2,4-triazoles via a formal cycloaddition reaction of hydrazonoyl chloride with NMI. The product was proved to be formed via an initial nucleophilic substitution of hydrazonoyl chloride with NMI following cyclization and two sequential C-N bond cleavages. This journal is

SYNTHESIS OF TRIAZOLES AND OXADIAZOLES FROM 2-ARYL-3-PHENYL-4-IMINO-5-CYANO-3,4-DIHYDROPYRIMIDINES

2-Aryl-3-phenyl-4-imino-5-cyano-3,4-dihydropyrimidines I were transformed to 1,2,4-triazoles II,IV and 1,2,4-oxadiazoles III by treatment with hydrazine, arylhydrazines or hydroxylamine in yields up to 90percent.