833450-25-2

Upstream product

• 833451-50-6 1-(3-chloro-2-fluoro-phenylamino)-7-methoxy-5-oxa-2,4,11-triazadibenzo[a,d]cyclopenten-8-ol 
• 7357-67-7 4-(3-chloropropyl)morpholine 
• 833451-52-8 6-chloro-N₄-(3-chloro-2-fluorophenyl)pyrimidine-4,5-diamine 
• 35094-87-2 2,4,5-trihydroxybenzaldehyde 
• 29865-97-2 2,5-dihydroxy-4-methoxy-benzaldehyde 
• 2106-04-9 3-chloro-2-fluoroaniline 

Relevant academic research and scientific papers

Efficient preparation of ((3-chloro-2-fluorophenyl)-[7-methoxy-8-(3- morpholin-4-yl-propoxy)-10,11-dihydro-5-oxa-2,4,11-triazadibenzo(a,d) cyclohepten-1-yl]-amine) for in-vivo study

An improved route for the preparation of highly functionalized 5,6-dihydropyrimido[4,5-b][1,4]oxazepine 1a in multigram quantities was developed. This new methodology was highlighted by the proper methoxy disposition via a regioselective methylation of 2,4,5-trihydroxy-benzaldehyde followed by a magnesium sulfate-promoted cyclization. Copyright Taylor & Francis LLC.