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833485-26-0

ethyl 2-(4-([1,1'-biphenyl]-2-carboxamido)phenyl)acetate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 833485-26-0 Structure

  • Basic information

    1. Product Name: ethyl 2-(4-([1,1'-biphenyl]-2-carboxamido)phenyl)acetate
    2. Synonyms: ethyl 2-(4-([1,1'-biphenyl]-2-carboxamido)phenyl)acetate
    3. CAS NO:833485-26-0
    4. Molecular Formula:
    5. Molecular Weight: 359.425
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 833485-26-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: ethyl 2-(4-([1,1'-biphenyl]-2-carboxamido)phenyl)acetate(CAS DataBase Reference)
    10. NIST Chemistry Reference: ethyl 2-(4-([1,1'-biphenyl]-2-carboxamido)phenyl)acetate(833485-26-0)
    11. EPA Substance Registry System: ethyl 2-(4-([1,1'-biphenyl]-2-carboxamido)phenyl)acetate(833485-26-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 833485-26-0(Hazardous Substances Data)

833485-26-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 833485-26-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,3,3,4,8 and 5 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 833485-26:
(8*8)+(7*3)+(6*3)+(5*4)+(4*8)+(3*5)+(2*2)+(1*6)=180
180 % 10 = 0
So 833485-26-0 is a valid CAS Registry Number.

833485-26-0Relevant articles and documents

Structural optimization and in vitro profiling of N-phenylbenzamide-based farnesoid X receptor antagonists

Schmidt, Jurema,Schierle, Simone,Gellrich, Leonie,Kaiser, Astrid,Merk, Daniel

, p. 4240 - 4253 (2018)

Activation of the nuclear farnesoid X receptor (FXR) which acts as cellular bile acid sensor has been validated as therapeutic strategy to counter liver disorders such as non-alcoholic steatohepatitis by the clinical efficacy of obeticholic acid. FXR antagonism, in contrast, is less well studied and potent small molecule FXR antagonists are rare. Here we report the systematic optimization of a novel class of FXR antagonists towards low nanomolar potency. The most optimized compound antagonizes baseline and agonist induced FXR activity in a full length FXR reporter gene assay and represses intrinsic expression of FXR regulated genes in hepatoma cells. With this activity and a favorable toxicity-, stability- and selectivity-profile it appears suitable to further study FXR antagonism in vitro and in vivo.

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