833486-28-5

Upstream product

• 19718-49-1 4-amino-3-iodobenzoic acid methyl ester 
• 107-19-7 propargyl alcohol 

Downstream Products

• 746622-08-2 3-(2-amino-5-methoxycarbonylphenyl)-1-propanol 
• 177478-63-6 2-oxo-1,2,3,4-tetrahydro-6-quinolinecarboxylic acid methyl ester 
• 62245-12-9 6-acetyl-3,4-dihydro-2(1H)-quinolinone 
• 746622-09-3 3-(2-amino-5-acetylphenyl)-1-propanol 

Relevant academic research and scientific papers

Synthesis of five-, six-, and seven-membered ring lactams by Cp*Rh complex-catalyzed oxidative N-heterocyclization of amino alcohols

A new effective catalytic system consisting of [Cp*RhCl 2]2/K2CO3 (Cp* = pentamethylcyclopentadienyl) for the lactamization of amino alcohols has been developed. As an example, the reaction of 3-(2-aminophenyl)-1-propanol in the presence of [Cp*RhCl2]2 (5.0% Rh) and K 2CO3 (10%) in acetone gives 3,4-dihydro-2(1H)-quinolinone in an isolated yield of 80%. A variety of five-, six-, and seven-membered benzo-fused lactams are synthesized by this catalytic system.