177478-63-6

Upstream product

• 833486-28-5 3-(2-amino-5-methoxycarbonylphenyl)-2-propyn-1-ol 
• 1123762-20-8 2-methoxy-3,4-dihydro-6-quinolinecarboxylic acid methyl ester 
• 1123762-06-0 methyl 4-{N-(1'-methoxy)cyclopropyl}amino-3-iodobenzoate 
• 1536478-49-5 methyl 4-formamido-3-vinylbenzoate 
• 1536478-88-2 C₉H₈BrNO₃ 
• 67-56-1 methanol 
• 70639-77-9 1,2,3,4-tetrahydro-2-oxo-6-quinolinecarboxylic acid 
• 19718-49-1 4-amino-3-iodobenzoic acid methyl ester 
• 746622-08-2 3-(2-amino-5-methoxycarbonylphenyl)-1-propanol 
• 208334-93-4 5-(pent-4-enoylamino)furan-2-carboxylic acid methyl ester 

Downstream Products

• 70639-78-0 1,2-dihydro-2-oxo-6-quinolinecarboxylic acid 
• 68882-86-0 2-oxo-1,2-dihydroquinoline-6-carboxylic acid methyl ester 
• 177478-49-8 methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate 

Relevant academic research and scientific papers

NEW BICYCLIC DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES

The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

FACTOR XIa INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

Regiodivergent access to five- and six-membered benzo-fused lactams: Ru-catalyzed olefin hydrocarbamoylation

We report herein a new strategy of the Ru-catalyzed intramolecular olefin hydrocarbamoylation for the regiodivergent synthesis of five- and six-membered benzo-fused lactams starting from N-(2-alkenylphenyl)formamides. Using a combined catalyst of Ru3

Novel approach to 3,4-dihydro-2(1H)-quinolinone derivatives via cyclopropane ring expansion

N-(1'-Alkoxy)cyclopropyl-2-haloanilines are transformed to 3,4-dihydro-2(1H)-quinolinones via palladium-catalyzed cyclopropane ring expansion. The reaction tolerates a variety of functional groups such as ester, nitrile, ether, and ketone group

Synthesis of five-, six-, and seven-membered ring lactams by Cp*Rh complex-catalyzed oxidative N-heterocyclization of amino alcohols

A new effective catalytic system consisting of [Cp*RhCl 2]2/K2CO3 (Cp* = pentamethylcyclopentadienyl) for the lactamization of amino alcohols has been developed. As an example, the reaction of 3-(2-aminophenyl)-1-propanol in the presence of [Cp*RhCl2]2 (5.0% Rh) and K 2CO3 (10%) in acetone gives 3,4-dihydro-2(1H)-quinolinone in an isolated yield of 80%. A variety of five-, six-, and seven-membered benzo-fused lactams are synthesized by this catalytic system.

IMDAF Cycloaddition as a Method for the Preparation of Pyrrolophenanthridine Alkaloids

Acylation of 5-amino-2-furancarboxylic acid methyl ester with alkenoyl acid chlorides gives 2-amidofurans that undergo intramolecular Diels-Alder cycloadditions. The reactions occur at 165°C in toluene or at 100°C when 4 M ethereal LiClO4 was u