833487-65-3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 194610-23-6 (R)-tert-butyl((4,4-dibromo-2-methylbut-3-en-1-yl)oxy)diphenylsilane 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 92817-88-4 (2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal 
• 95514-03-7 (S)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionic acid methyl ester 

Downstream Products

• 1042150-41-3 tert-Butyl-((Z)-(R)-4-iodo-2-methyl-pent-3-enyloxy)-diphenyl-silane 
• 833487-69-7 4-[(1SR,2Z,4R)-1-benzyloxycarbonylamino-4-carboxy-2-trimethylsilanylpent-2-enyl]benzoic acid methyl ester 
• 833487-59-5 4-[(1SR,2Z,4R)-1-benzyloxycarbonylamino-5-hydroxy-4-methyl-2-trimethylsilanylpent-2-enyl]benzoic acid methyl ester 
• 833487-68-6 4-[(1SR,2Z,4R)-1-benzyloxycarbonylamino-4-methyl-5-oxo-2-trimethylsilanylpent-2-enyl]benzoic acid methyl ester 
• 833487-58-4 C₄₅H₅₄NO₄PSi₂ 

Relevant academic research and scientific papers

Convergent approach to (E)-alkene and cyclopropane peptide isosteres

(Chemical Equation Presented) Trisubstituted (E)-alkene isosteres (TEADIs) and novel cyclopropane amide bond isosteres (CPDIs) were synthesized by aldimine addition and three-component aldimine addition-cyclopropanation methodologies, respectively. These

Imine additions of internal alkynes for the synthesis of trisubstituted (E)-alkene and cyclopropane peptide isosteres

Divergent multi-component reactions (DMCR) involving C-C bond formations can provide large increases in structural diversity and allow the rapid assembly of complex products from readily available starting materials. Cascade hydrozirconation-Zr/Zn transmetalation-imine addition of alkynes represents a versatile methodology for the synthesis of (E)-alkene and cyclopropane dipeptide isosteres. Appropriate substitutions at the sp2-carbon of (E)-alkene peptide isosteres allow a range of Pd-catalyzed cross-coupling reactions, which can be used for the fine-tuning of the conformational and electronic properties of the parent peptide bond mimic. C-C bond formation by microwave-accelerated Stille coupling of stannylalkenes represents a fast, convergent synthetic approach toward trisubstituted (E)-alkene dipeptide isosteres.