83366-66-9 Usage
Chemical Properties
Crystalline Solid
Originator
Dutonin,Bristol-Myers Squibb,USA
Uses
A selective serotonin 5-HT2 receptor antagonist. An antidepressant
Therapeutic Function
Antidepressant
Biological Functions
Although nefazodone (Serzone) is structurally related
to trazodone, it is less sedating. It does not block α1-
adrenoreceptors, and its use is not associated with priapism.
Nefazodone inhibits the neuronal reuptake of
serotonin and blocks 5HT2A receptors. Its short half-life
requires dosing twice a day. Nefazodone is
not associated with weight gain or sexual dysfunction. It
inhibits the cytochrome P450 3A4 isoenzyme that is responsible
for 50% of known oxidative metabolism, and
therefore, nefazodone can elevate levels of drugs dependent
on this pathway for metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 83366-66-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,3,6 and 6 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 83366-66:
(7*8)+(6*3)+(5*3)+(4*6)+(3*6)+(2*6)+(1*6)=149
149 % 10 = 9
So 83366-66-9 is a valid CAS Registry Number.
InChI:InChI=1/C25H32ClN5O2/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22/h3-6,8-11,20H,2,7,12-19H2,1H3
