83442-19-7

Upstream product

• 75-09-2 dichloromethane 
• 1666-13-3 diphenyl diselenide 
• 22859-16-1 tris(phenylselanyl)methane 
• 593-71-5 Chloroiodomethane 
• 23974-72-3 sodium phenylselenide 

Downstream Products

• 112211-76-4 methyl 2-oxo-1-((phenylseleno)methyl)cyclooctane-1-carboxylate 
• 127956-12-1 methyl 1-oxa-3-phenylselenomethylcyclohexan-4-one-3-carboxylate 
• 127956-06-3 methyl 4-oxo-3-phenylselenomethyl-1-triphenylmethyl-3-piperidinecarboxylate 
• 35050-01-2 α-(phenylseleno)acetophenone 
• 61759-13-5 1-(phenylselanyl)propan-2-one 
• 153908-42-0 iodo(phenylseleno)methane 
• 861391-83-5 phenylselenomethyl (E)-(2RS)-2-benzyl-4-(4-methoxyphenyl)-3-butenoate 
• 1011286-23-9 1-(tert-butyldiphenylsilyloxy)methyl-4-phenylthio-2-cyclopentenecarboxylic acid (phenylseleno)methyl ester 

Relevant academic research and scientific papers

Preparation method of antiviral phenyl selenide

The invention discloses a preparation method of an antiviral phenyl selenide. The method comprises the following steps: under nitrogen protection, by taking sodium borohydride as a reducing agent, reacting diphenyl diselenide with dichloromethane to synth

Thermodynamic properties of selenoether-functionalized ionic liquids and their use for the synthesis of zinc selenide nanoparticles

Three selenoether-functionalized ionic liquids (ILs) of N-[(phenylseleno)methylene]pyridinium (1), N-(methyl)- (2) and N-(butyl)-N'-[(phenylseleno)methylene]imidazolium (3) with bis(trifluoromethanesulfonyl)imide anions ([NTf2]) were prepared from pyridine, N-methylimidazole and N-butylimidazole with in situ obtained phenylselenomethyl chloride, followed by ion exchange to give the desired compounds. The crystal structures of the bromide and tetraphenylborate salts of the above cations (1-Br, 2-BPh4 and 3-BPh4) confirm the formation of the desired cations and indicate a multitude of different supramolecular interactions besides the dominating Coulomb interactions between the cations and anions. The vaporization enthalpies of the synthesized [NTf2]-containing ILs were determined by means of a quartz-crystal microbalance method (QCM) and their densities were measured with an oscillating U-tube. These thermodynamic data have been used to develop a method for assessment of miscibility of conventional solvents in the selenium-containing ILs by using Hildebrandt solubility parameters, as well as for modeling with the electrolyte perturbed-chain statistical associating fluid theory (ePC-SAFT) method. Furthermore, structure-property relations between selenoether-functionalized and similarly shaped corresponding aryl-substituted imidazolium- and pyridinium-based ILs were analyzed and showed that the contribution of the selenium moiety to the enthalpy of vaporization of an IL is equal to the contribution of a methylene (CH2) group. An incremental approach to predict vaporization enthalpies of ILs by a group contribution method has been developed. The reaction of these ILs with zinc acetate dihydrate under microwave irradiation led to ZnSe nanoparticles of an average diameter between 4 and 10 nm, depending on the reaction conditions.

Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights

Selenium-containing quinone-based 1,2,3-triazoles were synthesized using click chemistry, the copper catalyzed azide-alkyne 1,3-dipolar cycloaddition, and evaluated against six types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-11

Selenium compounds in Click Chemistry: Copper catalyzed 1,3-dipolar cycloaddition of azidomethyl arylselenides and alkynes

We described herein the use of selenium compounds in Click Chemistry by copper catalyzed 1,3-dipolar cycloaddition of azidomethyl arylselenides with alkynes. The reactions were performed under mild conditions reacting azidomethyl arylselenides with a rang

Ruthenium complexes of thiaporphyrin and dithiaporphyrin

Successful synthesis and characterization of the six-coordinated complex [Ru(STTP)(CO)Cl] (1; STTP = 5,10,15,20-tetratolyl-21-thiaporphyrinato) allowed the development of the coordination chemistry of ruthenium-thiaporphyrin through dechlorination and metathesis reactions. Accordingly, [RuII(STTP) (CO)X] (X = NO3- (2), NO2- (3), and N3- (4)) was synthesized and analyzed by single-crystal X-ray structural determination and NMR, UV-vis, and FT-IR spectroscopic methods. An independent reaction of STPPH and [Ru(COD)Cl2] led to [Ru III(STTP)Cl2] (5), which possessed a higher-valent Ru(III) center and exhibited good stability in the solution state. This stability allowed reversible redox processes in a cyclic voltammetric study. Reactions of [Ru(S2TTP)Cl2] (S2TTP = 5,10,15,20-tetratolyl- 21,23-dithiaporphyrinato) with AgNO3 and NaSePh, also via the metathesis strategy, resulted in novel dithiaporphyrin complexes [Ru II(S2TTP)(NO3)2] (6) and [Ru 0(S2TTP)(PhSeCH2SePh)2] (7), respectively. The structures of 6 and 7 were corroborated by X-ray crystallographic analyses. Complex 7 is an unprecedented ruthenium(0)- dithiaporphyrin with two bis(phenylseleno)methanes as axial ligands. A comparison of the analyses of the crude products from reactions of NaSePh and CH2Cl2 with or without [Ru(S2TTP)Cl 2], further supported by UV-vis spectral changes under stoichiometric reactions between [Ru(S2TTP)Cl2] and NaSePh, suggested a reaction sequence in the order of (1) formation of a putative [Ru II(S2TTP)(SePh)2] intermediate, followed by (2) the concerted formation of PhSe-CH2Cl and simultaneously a reduction of Ru(II) to Ru(0) and finally (3) nucleophilic substitution of PhSeCH 2Cl by excess PhSe-, resulting in PhSeCH2SePh, which readily coordinated to the Ru(0) and completed the formation of bis(phenylseleno)methane complex 7.

Imidazolium ionic liquids containing selenium: Synthesis and antimicrobial activity

The synthesis and antimicrobial profile of imidazolium ionic liquids containing selenium are described herein. Minimum inhibitory concentration revealed that these compounds are especially active against algae, and their activity is modulated by substitue

General synthesis of alkyl phenyl selenides from organic halides mediated by zinc in aqueous medium

Organic halides of different structural types react with diphenyl diselenide and zinc dust in aqueous medium to give alkyl phenyl selenides. Benzylic and allylic bromides, α-bromoesters, acids and ketones and some primary alkyl iodides produce high yields even under acidic conditions. Less reactive halides need basic medium. The reaction proceeds equally well in the presence of various unprotected functional groups. Control experiments support a SH2 mechanism via alkyl radicals.

A novel synthetic approach to β-arylselenenyl tertiary alcohols by the one-pot reaction of chloromethyl selenides and ketones promoted by samarium diiodide

At ambient temperature, β-arylselenenyl tertiary alcohols can be conveniently synthesized with samarium diiodide, chloromethyl selenides and ketones by one-pot method in high yields.

A convenient synthesis of arylselenoacetals and α-halo-α-(phenylseleno)alkanes

α-Halo-α-(phenylseleno)alkanes are prepared by treatment of selenoacetals with halogenating agents. Selenoacetals are produced by heating α-halo-α-(phenylseleno)alkanes on neutral alumina

Relative Reactivities of Various Sulfides, Selenides and Halides Towards SH2 Attack by Tributyltin Radicals

The order of reactivity towards SH2 attack by tributyltin radicals on various groups X in four different molecular environments (RCO2CH2X, RCH2OCH2X, XCH2CO2Et and RCH2X) has been found by competition experiments to be Br > PhSe > Cl > p-CNC6H4S > PhS > p-MeC6H4S > MeS.The mechanism of the reaction of chloromethyl phenyl sulfide with alkoxides is discussed.