83467-03-2Relevant academic research and scientific papers
SYNTHESIS OF 1,1-DIAMINO-2-THIOACYLETHYLENES: A NOVEL C-THIOACYLATION BY THE WILLGERODT-KINDLER REACTION
Rajappa, S.,Nair, M. D.,Sreenivasan, R.,Advani, B. G.
, p. 1673 - 1676 (2007/10/02)
A novel C-thioacylation reaction is described.Reaction of aromatic or heterocyclic aldehydes with 1-alkyl-2-methyl-1,4,5,6-tetrahydropyrimidine or 1-alkyl-2-methylimidazolidine in the presence of sulphur leads to the thioacylketeneaminals 6,10 or 12 in low to moderate yields.The structure of 6e was proved by S-methylation to 7e and acid-hydrolysis to the known 8e.Oxidative cyclization of 6 leads to the isothiazolo(2,3-a) pyrimidinium salts 13.
