83467-34-9

Usage

Uses

3,5-Dimethyl-4-(2-hydroxyethyl)isoxazole is used as a chemical intermediate for the synthesis of various compounds in the pharmaceutical and chemical industries. Its unique structure and functional groups make it a valuable building block for the development of new drugs and materials.
Used in Pharmaceutical Industry:
3,5-Dimethyl-4-(2-hydroxyethyl)isoxazole is used as a key component in the development of new pharmaceutical compounds. Its structure and functional groups can be utilized to create novel drug candidates with potential therapeutic applications.
Used in Chemical Industry:
3,5-Dimethyl-4-(2-hydroxyethyl)isoxazole is used as a starting material for the synthesis of various chemical products. Its unique structure and reactivity make it a valuable asset in the creation of new materials with specific properties and applications.

InChI:InChI=1/C7H11NO2/c1-5-7(3-4-9)6(2)10-8-5/h9H,3-4H2,1-2H3

Upstream product

• 35166-42-8 2-(3,5-dimethylisoxazol-4-yl)acetonitrile 
• 19788-37-5 4-chloromethyl-3,5-dimethylisoxazole 
• 113618-89-6 ethyl 2-(3,5-dimethylisoxazol-4-yl)acetate 
• 18835-02-4 ethyl 3-acetyl-4-oxopentanoate 
• 695-70-5 1,1-diacetylcyclopropane 

Relevant academic research and scientific papers

PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN 1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.

HYDROXYL PURINE COMPOUNDS AND USE THEREOF

Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNFα inhibitors, in particular, the compounds as shown in formula (I), or tautomers thereof or pharmaceutically acceptable salts thereof.

Atom-Economic Synthesis of Fully Substituted 2-Aminopyrroles via Gold-Catalyzed Formal [3+2] Cycloaddition between Ynamides and Isoxazoles

A concise and flexible synthesis of fully substituted 2-aminopyrroles via gold-catalyzed formal [3+2] cycloaddition between ynamides and isoxazoles has been developed. Under mild reaction conditions, various 2-aminopyrrole derivatives were obtained in good to excellent yields, thus providing an efficient and atom-economic way for the construction of fully substituted 2-aminopyrroles. It was all very formal: A novel gold-catalyzed formal [3+2] cycloaddition between ynamides and isoxazoles has been developed, allowing the concise and flexible synthesis of fully substituted 2-aminopyrroles. Importantly, this strategy provides new mechanistic insights and offers an atom-economic way for the construction of fully substituted 2-aminopyrroles.

REARRANGEMENTS AND CYCLIZATIONS - XIV. RING-OPENING REACTIONS OF 1,1-DIACETYLCYCLOPROPANE WITH HYDRAZINE AND HYDROXYLAMINE DERIVATIVES AS THE NOVEL SYNTHESIS OF Β-X-ETHYL SUBSTITUTED PYRAZOLES AND ISOXAZOLES

The reactions of 1,1-diacetylcyclopropane (1) with a number of hydrazine and hydroxylamine derivatives proceed via cyclopropane ring opening with incorporation of external nucleophile (solvent) to give the 4-β-X-ethyl derivatives of 3,5-dimethylpyrazoles