83476-95-3Relevant academic research and scientific papers
A nickel(ii)-catalyzed asymmetric intramolecular Alder-ene reaction of 1,7-dienes
Liu, Wen,Zhou, Pengfei,Lang, Jiawen,Dong, Shunxi,Liu, Xiaohua,Feng, Xiaoming
, p. 4479 - 4482 (2019)
A highly diastereo- and enantioselective intramolecular Alder-ene reaction with an alkene as the enophile has been developed by using a chiral N,N′-dioxide/nickel(ii) complex as the catalyst. This protocol provides a facile route towards the synthesis of diverse 3,4-disubstituted chroman, tetrahydroquinoline, piperidine and thiochroman derivatives in high yields with good to excellent diastereo- and enantioselectivities.
