834885-04-0

Basic information

• Product Name: 1-(4-(3,5-DIMETHYLPHENOXY)PHENYL)ETHANONE
• Synonyms: 1-(4-(3,5-DIMETHYLPHENOXY)PHENYL)ETHANONE;SALOR-INT L499420-1EA
• CAS NO: 834885-04-0
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.3
• Mol File: 834885-04-0.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-(3,5-DIMETHYLPHENOXY)PHENYL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(3,5-DIMETHYLPHENOXY)PHENYL)ETHANONE(834885-04-0)
• EPA Substance Registry System: 1-(4-(3,5-DIMETHYLPHENOXY)PHENYL)ETHANONE(834885-04-0)

Safety Data

• Hazardous Substances Data: 834885-04-0(Hazardous Substances Data)

Usage

Description

1-(4-(3,5-DIMETHYLPHENOXY)PHENYL)ETHANONE, also known as 1-(4-(3,5-dimethylphenoxy)phenyl)ethanone, is a chemical compound with the molecular formula C18H18O2. It belongs to the class of organic compounds known as phenones, which are compounds containing a ketone group attached to a phenyl group. This chemical is characterized by its unique structure and properties, making it a versatile compound for various applications.

Uses

1. Used in Pharmaceutical Applications:
1-(4-(3,5-DIMETHYLPHENOXY)PHENYL)ETHANONE is used as a building block for the synthesis of other compounds in the pharmaceutical industry. Its unique structure allows for the development of new drugs with potential biological and pharmacological activities.
2. Used in Industrial Applications:
1-(4-(3,5-DIMETHYLPHENOXY)PHENYL)ETHANONE is also utilized in various industrial applications, where it serves as a key component in the production of different products. Its versatility and chemical properties make it a valuable compound for research and development in various sectors.

Upstream product

• 99-91-2 para-chloroacetophenone 
• 108-68-9 3,5-Dimethylphenol 
• 13329-40-3 4-Iodoacetophenone 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 1431875-99-8 2-(4-(3,5-dimethylphenoxy)phenyl)-6-fluoroquinoline-4-carboxylic acid 

Relevant articles and documents

Nickel-Catalyzed Etherification of Phenols and Aryl Halides through Visible-Light-Induced Energy Transfer

Notwithstanding some progress in nickel-catalyzed etherification of alkanols and arylhalides, the ability of such a Ni-catalyzed transformation employing phenols to diaryl ethers is unsuccessful due to phenolates with much lower reduction potentials, which suppress the oxidation of nickel(II) intermediates into requisite Ni(III) species. We herein report visible-light-initiated, nickel-catalyzed O-arylation of phenols with arylhalides using t-BuNH(i-Pr) as the base and thioxanthen-9-one as the photosensitizer under visible light. This photocoupling exhibits a broad substrate scope.

N-Picolinamides as ligands in Ullman type C–O coupling reactions

Copper-catalyzed modified Ullmann coupling reactions creating C–O bonds, including diaryl ethers or phenols, are vital to organic synthesis. Synthesized N-phenyl-2-pyridinecarboxamide and its derivatives were used as ligands in conjunction with catalytic copper sources in the formation of various diaryl ethers and phenols. Various aryl and heteroaryl halides with electron donating and withdrawing groups were reacted with various phenols under mild reaction conditions providing moderate to excellent yields.

Green alternative solvents for the copper-catalysed arylation of phenols and amides

Investigation of the use of green organic solvents for the Cu-catalysed arylation of phenols and amides is reported. Alkyl acetates proved to be efficient solvents in the catalytic processes, and therefore excellent alternatives to the typical non-green solvents used for Cu-catalysed arylation reactions. Solvents such as isosorbide dimethyl ether (DMI) and diethyl carbonate also appear to be viable possibilities for the arylation of phenols. Finally, a novel copper catalysed acyl transfer process is reported.