835-78-9

Basic information

• Product Name: 2-PHENETHYLBENZYL ALCOHOL
• Synonyms: 2-PHENETHYLBENZYL ALCOHOL;o-phenethylbenzyl alcohol;2-(2-Phenylethyl)benzenemethanol;2-(2-Phenylethyl)benzyl alcohol;2-Phenethylbenzenemethanol;[2-(2-phenylethyl)phenyl]methanol;2-Phenethylbenzyl alcohol 98%
• CAS NO: 835-78-9
• Molecular Formula: C₁₅H₁₆O
• Molecular Weight: 212.29
• EINECS: 212-644-1
• Product Categories: Alcohols;C9 to C30;Oxygen Compounds
• Mol File: 835-78-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 56-59 °C(lit.)
• Boiling Point: 330.7 °C at 760 mmHg
• Flash Point: 136.3 °C
• Appearance: /
• Density: 1.078 g/cm³
• Vapor Pressure: 6.53E-05mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-PHENETHYLBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENETHYLBENZYL ALCOHOL(835-78-9)
• EPA Substance Registry System: 2-PHENETHYLBENZYL ALCOHOL(835-78-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 835-78-9(Hazardous Substances Data)

Usage

Uses

2-Phenethylbenzyl alcohol was used to prepare reagent required during the synthesis of non-symmetric cyclic sulfamide HIV-1 protease inhibitors.

General Description

2-Phenethylbenzyl alcohol reacts with phosphorous tribromide to yield 2-phenethylbenzyl bromide.

InChI:InChI=1/C15H16O/c16-12-15-9-5-4-8-14(15)11-10-13-6-2-1-3-7-13/h1-9,16H,10-12H2

Upstream product

• 5505-02-2 ethyl 2-phenethylbenzoate 
• 17376-04-4 2-phenethyl iodide 
• 5159-41-1 2-iodobenzyl alcohol 
• 100-39-0 benzyl bromide 
• 74785-02-7 (2-(bromomethyl)phenyl)methanol 
• 194605-53-3 methyl 2-(2-phenylethyl)benzoate 
• 4890-85-1 o-phenethylbenzoic acid 

Downstream Products

• 833-48-7 dibenzosuberane 
• 194418-07-0 2-(2-phenylethyl)benzaldehyde tosylhydrazone 
• 1268267-86-2 1',3'-dimethyl-3-phenyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione 
• 1268267-70-4 1,3-dimethyl-5-(2-phenethylbenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 194418-09-2 1-Diazomethyl-2-phenethyl-benzene 
• 78920-30-6 1-benzylbenzocyclobutene 
• 22253-11-8 2-phenyl-2,3-dihydro-1H-indene 

Relevant articles and documents

Transformation of Trifluorotoluenes Triggered by Titanium(IV) Chloride-Catalyzed Hydrodefluorination using Hydrosilanes

The titanium tetrachloride-catalyzed hydrodefluorination reaction of trifluorotoluene derivatives was developed using triethylsilane as the reducing agent. The reaction produced various toluene derivatives with high chemoselectivities by means of readily accessible reagents. This hydrodefluorination process was extended to the intramolecular Friedel-Crafts benzylation reaction, furnishing polycyclic aromatics of various ring sizes in good yields.

Direct synthesis of water-tolerant alkyl indium reagents and their application in palladium-catalyzed couplings with aryl halides

A direct result: Alkyl indium reagents are synthesized by the insertion of indium into alkyl halide mediated by CuCl. The synthetic utility of these reagents is demonstrated by their palladium-catalyzed coupling with aryl halides (see scheme). The reagents are compatible with various functional groups, and this makes the protocol generally useful in organic synthesis. DMA=N,N-dimethylacetamide, TBS=tert-butyldimethylsilyl.

Modulation of pharmacological profile of diphenylethane (lefetamine- type) derivatives

With the aim to split the pharmacological properties of lefetamine (CAS 14148-99-3), some structural modifications of this compound have been studied. The basic group of lefetamine has been shifted from the alkyl chain to the vicinal phenyl ring and the N-substitution has been changed. The dimethylaminomethyl derivatives and chiefly the o-morpholinometyhl exhibited a strong anti-visceral chemical antinociception activity stripped of thermal antinociception properties and physical dependence liability. Furthermore through the introduction of a diethylaminomethyl group in the lefetamine structure some derivatives were selected exhibiting besided a significant increase in the anti-visceral chemical antinociception activity, remarkable local anesthetic properties.