74785-02-7

Basic information

• Product Name: 2-(BROMOMETHYL)BENZYL ALCOHOL, 95%
• Synonyms: 2-(Bromomethyl)benzenemethanol, 2-Hydroxymethylbenzylbromide;BenzeneMethanol, 2-(broMoMethyl)-;(2-(broMoMethyl)phenyl)Methanol;2-(BroMoMethyl)benzyl alcohol 95%
• CAS NO: 74785-02-7
• Molecular Formula: C₈H₉BrO
• Molecular Weight: 201.07
• Product Categories: Alcohols;Building Blocks;C7 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 74785-02-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 66-68 °C
• Boiling Point: 279.551°C at 760 mmHg
• Flash Point: 152.617°C
• Appearance: /
• Density: 1.515g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: 2-8°C
• PKA: 14.18±0.10(Predicted)
• CAS DataBase Reference: 2-(BROMOMETHYL)BENZYL ALCOHOL, 95%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BROMOMETHYL)BENZYL ALCOHOL, 95%(74785-02-7)
• EPA Substance Registry System: 2-(BROMOMETHYL)BENZYL ALCOHOL, 95%(74785-02-7)

Safety Data

• Hazard Codes: C,N
• Statements: 22-34-43-50
• Safety Statements: 26-28-36/37/39-45-61
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 74785-02-7(Hazardous Substances Data)

Usage

General Description

2-(Bromomethyl)benzyl alcohol, 95% is a chemical compound frequently used in organic synthesis. It falls under the category of alkyl halides and alcohols, specifically benzyl alcohols. The compound has a benzene ring attached to a bromomethyl group and a hydroxyl group. It is noted for its efficiency and utility in the synthesis of different types of complex molecules, making it a key reagent in numerous research and industrial applications. The 95% signifies the purity of the compound, indicating that 95% of the content is 2-(Bromomethyl)benzyl alcohol, while the remaining 5% may consist of impurities.

InChI:InChI=1/C8H9BrO/c9-5-7-3-1-2-4-8(7)6-10/h1-4,10H,5-6H2

Upstream product

• 1634-04-4 tert-butyl methyl ether 
• 558-13-4 carbon tetrabromide 
• 612-14-6 phthalyl alcohol 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 85-44-9 phthalic anhydride 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 7115-89-1 2-(bromomethyl)benzoic acid 

Downstream Products

• 344339-67-9 2-<2-(hydroxymethyl)-phenylmethylthio>-1,3-benzoxazole 
• 107287-18-3 9-ethyl-1-<(2-hydroxymethyl)benzyl>adenine hydrobromide 
• 251961-48-5 2-(furfuryloxymethyl)benzyl alcohol 
• 213039-60-2 2,10-dihydroxy-6-[(2-(hydroxymethyl)benzyl)amino]-13-(β-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione 
• 897388-19-1 (2-(but-3-yn-1-yl)phenyl)methanol 
• 148671-87-8 1-(bromomethyl)-2-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzene 

Relevant articles and documents

Low-valent dialkoxytitanium(ii): a useful tool for the synthesis of functionalized seven-membered ring compounds

Herein, we describe unprecedented access to all-carbon or heterocyclic seven-membered ring frameworks from 1,8-ene-ynes promoted by inexpensive low-valent titanium(ii) species, readily available from Ti(OiPr)4and Grignard reagent. A broad range of cycloheptane, azepane or oxepane derivatives has been obtained (19 examples) with moderate to good yields and an excellent selectivity (up to 95/5 d.r.).

Enantioselective Synthesis of Indolines, Benzodihydrothiophenes, and Indanes by C?H Insertion of Donor/Donor Carbenes

We employ a single catalyst/oxidant system to enable the asymmetric syntheses of indolines, benzodihydrothiophenes, and indanes by C?H insertion of donor/donor carbenes. This methodology enables the rapid construction of densely substituted five-membered rings that form the core of many drug targets and natural products. Furthermore, oxidation of hydrazones to the corresponding diazo compounds proceeds in situ, enabling a relatively facile one- or two-pot protocol in which isolation of potentially explosive diazo alkanes is avoided. Regioselectivity studies were performed to determine the impact of sterics and electronics in donor/donor metal carbene C?H insertions to form indolines. This methodology was applied to a variety of substrates in high yield, diastereomeric, and enantiomeric ratios and to the synthesis of a patented indane estrogen receptor agonist with anti-cancer activity.

POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS

The invention features a hybridized polynucleotide construct containing a passenger strand, a guide strand loadable into a RISC complex, and (i) a 3'-terminal or an internucleotide non-bioreversible group in the guide strand; or (ii) a 5'-terminal, a 3'-terminal, or an internucleotide non-bioreversible group in the passenger strand, and a 5'-terminal, a 3'-terminal, or an internucleotide disulfide bioreversible group in the guide strand or the passenger strand. The invention also features methods of delivering a polynucleotide to a cell using the hybridized polynucleotide construct. The invention further features methods of reducing the expression of a polypeptide in a cell using the hybridized polynucleotide construct.