83507-17-9Relevant academic research and scientific papers
Synthesis of some new thiazolidin-5-one derivatives of pharmaceutical interest
Metwally,Keshk,Fekry,Etman
, p. 2067 - 2079 (2007/10/03)
Condensation of thiazolidin-5-one derivative 1 with different aromatic aldehydes gave the corresponding arylidenes 2a-e. Compound 2e was reacted with urea and thiourea to give the corresponding thiazolo[5,4-d]pyrimidine derivatives 3a,b, respectively. Treatment of compound 1 with phenyl isothiocyanate in basic DMF gave the nonisolable potassium salt of the adduct 4, which underwent heterocyclization upon treatment with chloroacetyl chloride and phenacyl bromide to give the corresponding [2,4′] bisthiazolidinylidenes 5 and 8. Moreover, the reactions of compound 1 with a variety of reagents, e.g., ninhydrin and isatin, were investigated. The structures of these compounds were established by analytical and spectral data.
A FACILE SYNTHESIS OF THIAZOLIDIN-5-ONES AND THEIR STRUCTURAL ASSINGMENT
Okawara, Tadashi,Nakayama, Kentaro,Furukawa, Mitsuru
, p. 1571 - 1574 (2007/10/02)
The reaction of 1,3-disubstituted thioureas (I) with α-halacyl halides (II) was found to afford thiazolidin-5-ones (IV) in 5percent sodium hydroxide-dichloromethane in the yields of 34-89percent.The structures of IV were discussed in details.
