83522-07-0

Basic information

• Product Name: 2-(p-(Dimethylamino)phenyl)-3-methyloxazolidine
• Synonyms: 2-(p-(Dimethylamino)phenyl)-3-methyloxazolidine
• CAS NO: 83522-07-0
• Molecular Formula: C₁₂H₁₈N₂O
• Molecular Weight: 0
• Mol File: 83522-07-0.mol

Chemical Properties

• Boiling Point: 309.7°C at 760 mmHg
• Flash Point: 91.7°C
• Appearance: /
• Density: 1.068g/cm³
• Vapor Pressure: 0.000628mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: 2-(p-(Dimethylamino)phenyl)-3-methyloxazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(p-(Dimethylamino)phenyl)-3-methyloxazolidine(83522-07-0)
• EPA Substance Registry System: 2-(p-(Dimethylamino)phenyl)-3-methyloxazolidine(83522-07-0)

Safety Data

• Hazardous Substances Data: 83522-07-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(p-(Dimethylamino)phenyl)-3-methyloxazolidine is used as a chiral auxiliary for enhancing the enantioselectivity of reactions in the synthesis of pharmaceutical compounds. Its ability to induce high levels of enantioselectivity is crucial for the production of enantiomerically pure drugs, which is essential for ensuring the desired therapeutic effects and minimizing potential side effects.
Used in Chemical Industry:
In the chemical industry, 2-(p-(Dimethylamino)phenyl)-3-methyloxazolidine serves as a chiral ligand in organic synthesis. It is instrumental in the development of new chemical processes and the production of enantiomerically pure compounds, which are vital for various applications, including the creation of specialty chemicals, agrochemicals, and fragrances.
Used in Asymmetric Synthesis:
2-(p-(Dimethylamino)phenyl)-3-methyloxazolidine is utilized as a chiral auxiliary in asymmetric synthesis for the production of chiral amino alcohols and amines. These chiral compounds are fundamental building blocks in the synthesis of biologically active molecules and are crucial for the development of new pharmaceuticals and agrochemicals.
Overall, 2-(p-(Dimethylamino)phenyl)-3-methyloxazolidine is a versatile chemical compound with significant applications across various industries, particularly in enhancing the selectivity and efficiency of chemical reactions to produce enantiomerically pure products.

InChI:InChI=1/C12H18N2O/c1-13(2)11-6-4-10(5-7-11)12-14(3)8-9-15-12/h4-7,12H,8-9H2,1-3H3

Upstream product

• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 100-10-7 4-dimethylamino-benzaldehyde 

Downstream Products

• 151696-87-6 2-[(4-Dimethylamino-benzyl)-methyl-amino]-ethanol 

Relevant articles and documents

Reductive Cleavage of N-Substituted 2-Aryl-1,3-oxazolidines: Generation of α-Amino-Substituted Carbanions

The behavior of several N-substituted 2-aryl-1,3-oxazolidines has been investigated under conditions of electron transfer from alkali metals in aprotic solvents.The reduction led to the regioselective cleavage of the benzylic carbon-oxygen bond, with formation of the corresponding N-substituted benzylamino alcohols in good yields.Investigation of the mechanism of this reductive cleavage, with the aid of labeling experiments, showed the intermediate formation of α-tertiary amino-substituted carbanions.

Comparative radioprotective activity of various pentagonal compounds with two heteroatomes

Various heterocyclic compounds with two heteroatomes were synthesized and their potential radioprotective activity was tested. This study shows the interest of phenylthiazolidines derivatives in chemical radioprotection.