83526-55-0Relevant articles and documents
Synthesis and biophysical characterization of chlorambucil anticancer ether lipid prodrugs
Pedersen, Palle J.,Christensen, Mikkel S.,Ruysschaert, Tristan,Linderoth, Lars,Andresen, Thomas L.,Melander, Fredrik,Mouritsen, Ole G.,Madsen, Robert,Clausen, Mads H.
supporting information; experimental part, p. 3408 - 3415 (2010/03/31)
The synthesis and biophysical characterization of four prodrug ether phospholipid conjugates are described. The lipids are prepared from the anticancer drug chlorambucil and have C16 and C18 ether chains with phosphatidylcholine or phosphatidylglycerol he
Synthesis and biological activity of anticancer ether lipids that are specifically released by phospholipase A2 in tumor tissue
Andresen, Thomas L.,Jensen, Simon S.,Madsen, Robert,J?rgensen, Kent
, p. 7305 - 7314 (2007/10/03)
The clinical use of anticancer lipids is severely limited by their ability to cause lysis of red blood cells prohibiting intravenous injection. Novel delivery systems are therefore required in order to develop anticancer ether lipids (AELs) into clinicall