83526-65-2

Upstream product

• 4145-51-1 3-O-Benzyl-1-O-octadecanoyl-sn-glycerin 
• 75-36-5 acetyl chloride 
• 56552-80-8 (R)-3-benzyloxy-1,2-propanediol 
• 112-76-5 Stearoyl chloride 
• 100-39-0 benzyl bromide 
• 16495-03-7 (S)-4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane 
• 100-44-7 benzyl chloride 

Downstream Products

• 79549-26-1 2-O-Acetyl-1-O-octadecanoyl-sn-glyceryl-3-phosphorylcholin 
• 219996-70-0 Octadecanoic acid (R)-2-acetoxy-3-{benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,6-bis-benzyloxymethoxy-3,4,5-tris-(4-methoxy-benzyloxy)-cyclohexyloxy]-phosphoryloxy}-propyl ester 
• 219996-73-3 Octadecanoic acid (R)-2-acetoxy-3-[benzyloxy-((1S,2R,3R,4S,5S,6R)-2,6-bis-benzyloxymethoxy-3,4,5-trihydroxy-cyclohexyloxy)-phosphoryloxy]-propyl ester 
• 228406-19-7 Octadecanoic acid (R)-2-acetoxy-3-(benzyloxy-diisopropylamino-phosphanyloxy)-propyl ester 

Relevant academic research and scientific papers

Phosphorylation of unnatural phosphatidylinositols with phosphatidylinositol 3-kinase

Phosphatidylinositol analogs (PI(C2)-PI(C18)) having a series of saturated fatty acid (C2-C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3- kinase). The reactivity of Pica with PI 3-kinase turned out to be comparable to that of natural PI, although PI(C18) was not phosphorylated under the same condition. The chirality of sn-2 center was not responsible for the phosphorylation reaction. (C) 2000 Elsevier Science Ltd.

Synthesis of diacylglycerol analogs of phosphatidylinositol 3,4,5- trisphosphate

Phosphatidylinositol 3,4,5-trisphosphate analogs with saturated diacylglycerol substructure have been designed, focusing on their reactivity with PIP3 5-phosphatase. Dephosphorylation of native PIP3 was competitively inhibited in the presence of synthetic PIP3(C2) and PIP3(C4), respectively.