83528-08-9

Upstream product

• 99-54-7 3,4-dichloronitrobenzene 
• 17639-93-9 2-chloro-propionic acid methyl ester 
• 121-73-3 3-Nitrochlorobenzene 
• 88975-09-1 2-(2-Chloro-4-nitro-phenyl)-2-methyl-malonic acid diethyl ester 

Downstream Products

• 83528-19-2 2-[2-Chloro-4-(pyridin-2-ylamino)-phenyl]-propionic acid methyl ester 
• 83528-37-4 2-[2-Chloro-4-(pyridin-2-ylamino)-phenyl]-propionic acid 
• 83528-13-6 2-(4-Amino-2-chloro-phenyl)-propionic acid methyl ester 

Relevant academic research and scientific papers

Nucleophilic substitution process combined with additional reaction steps

Halonitroarylacetic acid esters are prepared by reacting a halonitroaromatic compound with an alpha,alpha-disubstituted acetic acid ester in an inert solvent and in the presence of a base. The halonitroarylacetic acid esters formed by the process can be readily converted into derivatives, such as pharmaceuticals.

Nonsteroidal antiinflammatory agents. 2. [(Heteroarylamino)phenyl]alkanoic acids

A series of [(heteroarylamino)phenyl]alkanoic acids pyridine, quinoline, or pyrimidine as the heteroaryl moiety was prepared as potential antiinflammatory agents. Among them, 2-[4-(2-pyridylamino)phenyl]propionic acid (14b) showed excellent antiinflammatory and analgesic activities with less tendency to cause gastric side effects. Structure-activity relationships are discussed.